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GlossaryLgr5 (Leucine-rich repeat-containing G-protein coupled receptor 5)

protein marker for adult stem cells in hair follicles

Lgr5, or Leucine-rich repeat-containing G-protein coupled receptor 5, is a protein that serves as a marker for adult stem cells in various tissues, including hair follicles. It plays a crucial role in the regeneration and repair of these tissues, making it significant in studies related to hair growth and alopecia.

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research Constitutive Internalization of the Leucine-Rich G Protein-Coupled Receptor-5 (LGR5) to the Trans-Golgi Network

58 citations , February 2013 in “Journal of Biological Chemistry”

LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.

research Regulation of Stem Cell Function by Protein Ubiquitylation

55 citations , March 2014 in “EMBO Reports”

Protein ubiquitylation is crucial for controlling stem cell functions and could be targeted for cancer treatment.

research Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss

56 citations , May 2017 in “Nature Cell Biology”

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

research Nanotechnology-Based Techniques for Hair Follicle Regeneration

October 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

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community Carnitine Tartrate + Potassium chloride + Niacin

8 upvotes 11 years ago

The post discusses using Carnitine Tartrate, Potassium Chloride, and Niacin to reduce hair shedding, with the user experiencing significant improvement. The user also suggests considering a ketogenic/paleo diet for those with insulin resistance-related hair loss.

community Indian Subcontinent specific : Fin effects

in Finasteride/Dutasteride 6 upvotes 5 years ago

Oral finasteride is recommended over topical finasteride for men in the Indian subcontinent, with no reported side effects. Minoxidil and dermarolling are also suggested, while dietary supplements and topical finasteride are deemed less effective.

community Is EAA good or bad for hair? I cant find Any information about it.

in Product 1 upvotes 4 years ago

The conversation is about whether an EAA supplement affects hair health. The user lists the ingredients but does not receive a definitive answer.

community DIY NutraKos-style 6–amino-acid mix (recipe + references)

in Product 1 upvotes 1 month ago

A user shared a DIY recipe for a NutraKos-style amino acid mix as a cost-effective alternative to the expensive product, suggesting it as a complementary supplement for hair loss. Another user argued that proven treatments like finasteride and minoxidil are more reliable, questioning the efficacy of the amino acid mix.

community 30M Experiencing Shedding After Restarting Min + Fin + Mesotherapy, Is It Too Late?

bloodyreptar in General 168 upvotes 4 months ago

A 30-year-old is seeking advice on hair loss treatment, currently using oral minoxidil, finasteride, mesotherapy, and a supplement. They are experiencing shedding and are anxious about the effectiveness of the treatment, asking if they should continue or consider other options like topicals or microneedling.