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    GlossaryTopical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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      learn Fluridil

      a topical anti-androgen with less systemic involvement

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      powerful topical and oral anti-androgen used mostly by women

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      a novel topical treatment that inhibits DHT on androgen receptors

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      a potent but unapproved and potentially problematic topical anti-androgen

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      hormone commonly taken for sleep aid has some topical benefits for hair