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    Glossary Topical Antiandrogens

    medications applied to skin to block androgen effects locally

    Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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    1. Fluridil Topical anti-androgen sold as a cosmetic lotion
    2. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    3. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    4. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    5. RU58841 Experimental topical anti-androgen sold as a research chemical