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    Glossary Androgen Insensitivity Syndrome

    genetic condition causing resistance to male hormones in XY individuals

    Androgen Insensitivity Syndrome (AIS) is a genetic condition where a person who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. This can lead to a range of physical manifestations, from completely typical female external genitalia to ambiguous genitalia, depending on the degree of insensitivity.

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    1. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    2. Fluridil Topical anti-androgen sold as a cosmetic lotion
    3. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    4. RU58841 Experimental topical anti-androgen sold as a research chemical
    5. Bicalutamide Nonsteroidal anti-androgen, originally a prostate cancer drug