The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.
This study found that sweat gland stem cells primarily maintain sweat gland homeostasis but can trans-differentiate to aid in epidermal healing and regenerate diverse skin structures under certain conditions.
This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.
14 citations
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January 2020 in “International Journal of Biological Sciences”
This study explored the use of multiphoton microscopy to monitor changes in tumors and surrounding tissues in breast cancer patients undergoing neoadjuvant chemotherapy, finding it may effectively detect treatment response at cellular levels without using exogenous contrast agents.
The conversation humorously discusses using off-label drugs like Minoxidil, finasteride, and RU58841 for hair growth. It jokes about the brain absorbing these treatments for maximum keratin production.
Minoxidil is highly toxic to pets, and there is a call for manufacturers to add a "Toxic to Pets" warning on packaging. A petition has been started to raise awareness and prevent pet fatalities.
The conversation humorously discusses the unfairness of hair loss, highlighting various treatments like finasteride, minoxidil, red light therapy, and experimental drugs, while contrasting with people who have great hair despite unhealthy lifestyles. The original poster mentions experiencing side effects from switching to oral finasteride.
Counterfeit minoxidil can be identified by inconsistencies in bottle fill levels, label details, and smell compared to genuine products. Genuine minoxidil has a specific alcohol-based smell and consistency, while counterfeit versions may smell musky and feel greasy.
The user has been using finasteride, minoxidil, and derma stamping for hair loss but is considering switching to dutasteride due to lack of improvement. They are seeking advice on obtaining dutasteride, which is off-label in Denmark, and are considering ordering it online if not prescribed.
Does stopping finasteride mean losing all progress? Here's what really happens.Studies and the drug label report that finasteride's benefit lasts only while it is taken: after stopping, scalp DHT returns to baseline and hair loss resumes over roughly 6 to 12 months. Stopping a prescription drug is a decision to make with the prescriber.
Heavy duty finasteride that comes with higher risks
Will I notice changes in my body if I start taking dutasteride?Dutasteride lowers DHT, so labels and trials describe prostate shrinkage over 3-6 months and, off-label, slowed hair loss; the same sources list sexual side effects and an observational link to depression.
Dutasteride side effects: what the label and studies actually reportThe Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.
How does Botox target the tension that may be blocking your hair growth?Botox for hair loss is experimental and off-label: one small open-label pilot study of 50 men reported an 18% hair-count increase, but there is no placebo-controlled trial and the proposed scalp blood-flow mechanism has never been measured in patients.