The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.
This study found that sweat gland stem cells primarily maintain sweat gland homeostasis but can trans-differentiate to aid in epidermal healing and regenerate diverse skin structures under certain conditions.
This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.
14 citations
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January 2020 in “International Journal of Biological Sciences”
This study explored the use of multiphoton microscopy to monitor changes in tumors and surrounding tissues in breast cancer patients undergoing neoadjuvant chemotherapy, finding it may effectively detect treatment response at cellular levels without using exogenous contrast agents.
The conversation humorously discusses using off-label drugs like Minoxidil, finasteride, and RU58841 for hair growth. It jokes about the brain absorbing these treatments for maximum keratin production.
Minoxidil is highly toxic to pets, and there is a call for manufacturers to add a "Toxic to Pets" warning on packaging. A petition has been started to raise awareness and prevent pet fatalities.
The conversation humorously discusses the unfairness of hair loss, highlighting various treatments like finasteride, minoxidil, red light therapy, and experimental drugs, while contrasting with people who have great hair despite unhealthy lifestyles. The original poster mentions experiencing side effects from switching to oral finasteride.
Counterfeit minoxidil can be identified by inconsistencies in bottle fill levels, label details, and smell compared to genuine products. Genuine minoxidil has a specific alcohol-based smell and consistency, while counterfeit versions may smell musky and feel greasy.
The user has been using finasteride, minoxidil, and derma stamping for hair loss but is considering switching to dutasteride due to lack of improvement. They are seeking advice on obtaining dutasteride, which is off-label in Denmark, and are considering ordering it online if not prescribed.
Does stopping finasteride mean losing all progress? Here's what really happens.Studies and the drug label report that finasteride's benefit lasts only while it is taken: after stopping, scalp DHT returns to baseline and hair loss resumes over roughly 6 to 12 months. Plan any stop with the prescriber, but the UK regulator (MHRA, May 2026) advises stopping finasteride 1 mg immediately and contacting a doctor if depression or suicidal thoughts develop.
Will I notice changes in my body if I start taking dutasteride?Dutasteride lowers DHT, so labels and trials describe prostate shrinkage over 3-6 months and, off-label, slowed hair loss; the same sources list sexual side effects that may persist after stopping, breast and semen changes, rare allergic reactions, and an observational link to depression.
Vasodilator used on the scalp and, at low doses, as a tablet
What are the side effects of minoxidil, and can oral minoxidil affect your heart?Minoxidil tablets are a blood-pressure drug whose US label carries a boxed warning for fluid around the heart (pericardial effusion, sometimes tamponade) and worsening angina; use for hair loss is off-label, and studies of low doses describe mostly mild effects but rare serious heart events. Do not start or change minoxidil without a doctor, and if chest pain, a racing heartbeat, breathlessness, fainting, swelling or rapid weight gain develop, stop and seek medical care.
How does RU58841 compare with minoxidil and finasteride?Minoxidil and finasteride (men only) are approved medicines with labels that list their side effects. RU58841 is an unapproved research chemical with no published human trial for hair loss, and a small 2026 study found it reaches the blood after scalp use.