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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    1. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    2. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    3. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    4. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    5. Alopecia universalis with IL-12-RB1 and STAT4 mutations effectively treated with upadacitinib JAAD Case Reports · 2024
    6. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    7. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    8. Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older Actas Dermo-Sifiliográficas · 2025
    9. Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials Postgraduate Medical Journal · 2025
    10. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
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    1. Baricitinib JAK inhibitor pill used for severe alopecia areata
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