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Glossary Interleukin-1

protein that regulates immune and inflammatory responses

Interleukin-1 (IL-1) is a type of protein called a cytokine that plays a crucial role in the body's immune and inflammatory responses. It helps regulate immune reactions by promoting the activation of white blood cells and the production of other inflammatory molecules. Elevated levels of IL-1 are often associated with conditions like autoimmune diseases and chronic inflammation.

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research A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations

11 citations , March 2013 in “Gene”

This study reported that the IL1A 4-bp indel polymorphism is associated with a reduced risk of alopecia areata in Chinese populations, possibly through miR-122 mediated regulation of IL-1α expression.

research Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata

1 citations , July 2012 in “Nasza Dermatologia Online”

This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.

Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

August 2018

In this animal study, treatment with Trachyspermum copticum seed extract significantly altered IL-1 and KGF/FGF-7 gene expression, improving dermatitis and hair growth in mice compared to controls and corticosteroids.

research A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control

2 citations , September 2004 in “Experimental Dermatology”

This study found that VR1 activation in human hair follicles inhibited hair growth by suppressing proliferation and promoting apoptosis, suggesting VR1 plays an important role in hair growth regulation.

research Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype

25 citations , July 1994 in “Journal of Cell Science”

This study found that polyomavirus large T-immortalized rat dermal papilla cells retain hair-inductive ability and provide a viable model for studying hair growth and cytokine expression.

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