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natural substance from Neem tree with medicinal and pesticidal properties
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5 / 59 resultslearn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Valproic acid
an anticonvulsant repurposed for hair loss via histone inhibition
learn Exosomes
Microscopic delivery system that sends growth-promoting signals to hair follicles
learn Caffeine
the stimulant you know and love can be used topically to stimulate hair
Research
5 / 1000+ resultsresearch Enhanced Ex Vivo Skin Retention of Bicalutamide Using a Nano-in-Micro Composite: Drug-Loaded Lipid Vesicles in a Dissolving Microarray Patch
The new drug delivery system improves bicalutamide skin retention for better treatment of hair loss.
research Construction of Large-Scale Bioengineered Hair Germs and In Vivo Transplantation
Bioengineered hair germs using special hydrogels can help regenerate hair follicles and treat hair loss.
research Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data
Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
research In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules
Hair follicles affect how well small molecules can pass through the skin, and this varies depending on the molecule's features.
research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro
Human hair follicles grown in vitro maintain normal keratin patterns and structure.
Community Join
5 / 1000+ resultscommunity Why liposomal finasteride and minoxidil may be better than traditional topical solutions.
Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.
community Progress: From June 2022 (7 months of min + fin) to now (1 year) — I’ve lost so much density in this period and I have no idea why. I was getting pretty good resultup until that point. Is there anything else I can try? I’ve tried min, fin, tretinoin, micro needling, and castor oil. I feel hopeless.
The user lost hair density after 7 months of using minoxidil and finasteride and is seeking advice on other treatments after trying tretinoin, microneedling, and castor oil. Suggestions include checking for scalp conditions like eczema or psoriasis, changing minoxidil brands, and questioning hair dryer use and finasteride dosage.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Peptides that Stop Hair Loss? | In-depth Literature Review Video
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.