Search

for
Search:

Community Join

5 / 43 results

community Hydrophobic Finasteride. Why don’t we have it?

6 upvotes 1 year ago

The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

23 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community Topical Finasteride that doesn’t go systematic is the cure

3 upvotes 1 year ago

Topical finasteride that doesn't penetrate the skin could potentially treat hair loss without side effects. Current challenges include finding a formulation that remains on the scalp without increasing blood levels.

community Topical finasteride making. Powder not disolving

4 upvotes 3 years ago

OP is trying to dissolve finasteride powder for a topical solution but faces issues with it not dissolving properly in ethanol or water. Users suggest methods like using a magnetic stirrer, shaking the mixture, or filtering out fillers, with some noting that finasteride is soluble in alcohol.

community Minoxidil results in 3 months after stopping fin

in Is this regrowth? 469 upvotes 1 year ago

The user stopped finasteride due to testicular aches and switched to minoxidil, seeing positive results in three months. They are considering topical finasteride but are cautious because of past side effects from oral use.

View more "hydrophobic finasteride" in community →

Research

5 / 1000+ results

research Core-shell nanocarriers based on PEGylated hydrophobic hyperbranched polyesters

7 citations , May 2016 in “European Polymer Journal”

This study found that biodegradable hyperbranched polyesters improved the solubility and loading capacity of hydrophobic drugs, with complete pyrene release achieved in 16 days under enzymatic conditions.

Niosomes as Carriers in Dermal Drug Delivery

research Niosomes as Carrier in Dermal Drug Delivery

15 citations , October 2012 in “InTech eBooks”

Niosomes are a promising and effective way to deliver drugs through the skin.

research Hyperbranched glycerol-based core-amphiphilic branched shell nanotransporters for dermal drug delivery

10 citations , May 2016 in “Polymer”

This study reports that novel core-ABS nanocarriers efficiently loaded with dexamethasone and finasteride show potential for dermal drug delivery, exhibiting non-toxic interactions with human keratinocyte cells and skin penetration.

research Core-shell and core-amphiphilic branched shell nanocarriers based on biodegradable hyperbranched polymers, as potential drug delivery systems

January 2016 in “Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver”

This study found that novel biodegradable nanocarriers with highly hydrophobic cores significantly increased the solubility and sustained release of hydrophobic drugs and dyes, showing promise for drug delivery applications.

research Unlocking finasteride's potential via carboxymethyl-β-cyclodextrin inclusion complex for androgenic alopecia

March 2025 in “Carbohydrate Polymer Technologies and Applications”

In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.

View more "hydrophobic finasteride" in research →

Learn

7 / 801 results

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

Finasteride for alopecia: the definitive guide to using it correctly. Finasteride 1 mg daily blocks DHT and, in trials, slowed hair loss in most men over 6 to 12 months, though some men do not respond and the benefit lasts only while the drug is taken. It is prescription-only and carries a pregnancy contraindication.
Do you want finasteride to penetrate better? The ideal solvent to maximize its effect. Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.
Is finasteride safe? Studies report that most men tolerate finasteride 1 mg, but case series, regulatory labelling and patient reports describe sexual, mood and cognitive effects that some say persisted after stopping, and how often that happens is not established. It is a prescription-only medicine and is contraindicated in pregnancy.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn RU58841

RU58841: What's the difference between minoxidil and finasteride? Minoxidil stimulates hair growth, while finasteride reduces DHT levels to prevent hair loss.

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

View more "hydrophobic finasteride" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →