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5 / 15 resultslearn GHK-Cu
a copper peptide showing promise in both regrowth and reversing gray hair
learn Melatonin
hormone commonly taken for sleep aid has some topical benefits for hair
learn Valproic acid
an anticonvulsant repurposed for hair loss via histone inhibition
learn Vitamin D
vitamin you should probably be taking for general health might also help your hair a little
Research
5 / 1000+ results![Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase](/images/research/e9999895-18fe-40f4-8d3f-9b53dd40d313/small/15380.jpg)
research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase
Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.
![5α-Reduced glucocorticoids: a story of natural selection](/images/research/399ca7ee-d7f0-422d-a36b-6b1e0b85f4f4/small/26132.jpg)
research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
![PNU 157706, a novel dual type I and II5α-reductase inhibitor](/images/research/04e264b0-d28d-4633-b8f5-beaf7747ba88/small/15567.jpg)
research PNU 157706, a novel dual type I and II5α-reductase inhibitor
PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
![Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates](/images/research/c1133907-1cfc-45ac-977d-db8aa89d2d70/small/12113.jpg)
research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates
Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
![Novel inhibitors of 5α-reductase](/images/research/ff6a59d6-b298-4437-8735-b49febe727b7/small/20479.jpg)
research Novel inhibitors of 5α-reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
Community Join
5 / 683 resultscommunity What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers
The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.
community FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.
Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.
community 11 month progress on a cocktail regiment
The user "Dismal_Library_2264" shared their 11-month progress on a hair loss treatment regimen. They used dutasteride, topical minoxidil, dermarolling, a hair serum, and specific shampoos. They experienced some side effects but were overall satisfied with the results.
community 8 months - 0.5mg dut, 80mg Ru58841, 5mg oral min, topical min at night, microneedle 1.5mm every other week
The conclusion of the conversation is that the user has experienced significant hair regrowth using a combination of medications, including dutasteride, RU58841, and minoxidil. They have not experienced any noticeable side effects and are considering a hair transplant in the future.