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      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

      learn Vitamin D

      vitamin you should probably be taking for general health might also help your hair a little

      learn GHK-Cu

      a copper peptide showing promise in both regrowth and reversing gray hair

      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

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      community Painkillers May Block Minoxidil

      in Research/Science  15 upvotes 2 weeks ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 month ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  52 upvotes 3 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Discussion: Keratin Microsphere Results

      in Treatment  30 upvotes 1 year ago
      Keratin microspheres may offer additional mechanisms to combat hair loss compared to minoxidil. The process to create these microspheres is relatively simple and can be done at home with basic equipment.