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    Did you mean Outer Root Sheath?
    Glossary Outer Root Sheath

    layer of cells surrounding and supporting the hair follicle

    The Outer Root Sheath (ORS) is a layer of cells that surrounds the hair follicle, providing structural support and playing a crucial role in the growth and cycling of hair. It extends from the epidermis down to the hair bulb and is involved in the regeneration of the hair follicle after shedding.

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    1. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021 · 14 citations
    2. Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation Journal of Bioscience and Bioengineering · 2026
    3. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
    4. Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath 2019 · 12 citations
    5. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell Tissue Engineering and Regenerative Medicine · 2020 · 9 citations
    6. Effects of Human Hair Outer Root Sheath Cell- and Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Human Hair Follicle Stem Cells Current Stem Cell Research & Therapy · 2026
    7. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. PubMed · 1993 · 61 citations
    8. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations
    9. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    10. SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata Journal of Dermatological Science · 2023 · 13 citations
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