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Research

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research Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions

2 citations , April 2019 in “Experimental Dermatology”

This study observed that applying a pulling force to hair follicles led to significant compression of nuclei in certain cell layers and distinct collagen changes at different follicle depths.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.

research Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix

9 citations , April 2019 in “International journal of molecular sciences”

In this study, growing human hair follicles in a defined glycosaminoglycan hydrogel ex vivo promoted cell survival, proliferation, and activation of hair growth-related signaling pathways, suggesting GAG-based hydrogels could modulate the hair follicle growth cycle.

research Regional differences in the distribution of melanocyte-containing hair bulbs in the skin of male albino rats

November 2025 in “PLoS ONE”

This study observed that albino rats, despite not producing melanin, have melanocytes localized in specific skin areas of their hair matrix, suggesting that gene expression analysis of their skin should consider regional differences in melanocyte presence.

The Extracellular Matrix Dictates Regional Competence for Tumor Initiation

research The extracellular matrix dictates regional competence for tumour initiation

24 citations , November 2023 in “Nature”

In this study, researchers demonstrated that the expression of the oncogene SmoM2 leads to basal cell carcinoma in the ear epidermis of mice but not in the back skin, with differences in susceptibility linked to the composition of the extracellular matrix.

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Community Join

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community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

158 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community I Recovered From Severe Hair Loss: My 8-Month Regrowth Recovery — Full Timeline, Photos & Treatment Data

35 upvotes 4 months ago

A 29-year-old male experienced significant hair regrowth over 8 months using a protocol of oral Minoxidil, Dutasteride, Pyrithione Zinc Shampoo, and peptides GHK-CU, BPC-157, and TB-500. The treatment led to improved scalp coverage, reduced hair loss, and thicker hair, although results may vary for others.

community Dental technician is convinced that he has found the cause of pattern hair loss

314 upvotes 2 years ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

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Learn

6 / 801 results

learn Thymosin Beta 4

learn Stem Cell Factor

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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Experts

1 / 5 results

Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas