19 citations
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January 2017 in “Stem Cells International”
This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.
This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.
April 2026 in “Journal of Dermatological Treatment”
This study concluded that in female pattern hair loss patients, CGF and i-PRF treatments were more effective than PRP in increasing target area hair count, with i-PRF having the lowest adverse event rate.
4 citations
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April 2024 in “Cellular and Molecular Biology”
In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.
PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hairgrowth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.
Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.
A 19-year-old is using finasteride, dutasteride, and minoxidil to combat hair loss, seeing improved hair density but minimal hairline regrowth. Users suggest patience, continued treatment, and possibly considering a hair transplant in the future.
Minoxidil and finasteride are the only FDA-approved treatments for androgenetic alopecia, while newer treatments like clascoterone, PP405, NV-623/624, AMP-303, and RU58841 are still experimental with varying levels of evidence. Clascoterone shows the most promise due to strong human data, while AMP-303 has notable early human trial results; RU58841 lacks human data and remains experimental.
Does capsicum improve scalp circulation or hairgrowth?Capsaicin dilates blood vessels through TRPV1 activation, so in theory capsicum could raise scalp blood flow (this has not been measured on the scalp in a hair-loss study), but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.
Does caffeine stimulate hairgrowth or only slow hair loss?Caffeine stimulates hair follicles in laboratory cultures, and one open-label, manufacturer-funded trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint. A 2025 systematic review found only a few small controlled trials, mostly rated low or very low quality, and none in alopecia areata.
Does lavender promote hairgrowth or just soothe an irritated scalp?A 2016 study found more hair growth in mice treated with lavender oil, but no trial has tested lavender alone for hair loss in people. Lavender oil can cause skin allergy, and case reports link lavender products to breast growth in children.
Does dexpanthenol promote hairgrowth?Reviews describe dexpanthenol mainly as a moisturiser for skin. No controlled trial has shown that it promotes hair growth.