Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.
41 citations
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September 2010 in “Journal of dermatological science”
This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hairfollicles in mice, indicating potential for developing hair cell therapy using stem cells.
19 citations
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April 2010 in “Journal of Dermatological Treatment”
This study found that partial follicular units extracted from the donor area can survive and regenerate new hairs at their original site and when transplanted, effectively creating two hairfollicles from one.
In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce folliclemultiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hairfollicles.
21 citations
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October 2009 in “Biochemical Engineering Journal”
This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
A breakthrough in hairfollicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hairfollicles suitable for transplantation. Clinical trials for this hairmultiplication technology are planned in partnership with Yinguan Biotechnology.
Hair cell therapy and follicle cloning are still in experimental stages, with treatments like hairmultiplication and regenerative hair therapy being marketed but not yet proven to create unlimited new follicles. There is skepticism about the effectiveness and legitimacy of these treatments, with some considering them scams.
The conversation discusses an interview with Dr. Tsuji about hairfollicle stem cell multiplication and the financial challenges of starting human clinical trials. It also mentions the need for funding to secure a patent for a protein that promotes hair growth.
Hair/scalp cloning for unlimited transplants is likely a decade away, with prior transplants not significantly affecting future options. Advances in AI and research in wound-induced hair neogenesis are promising, but infrastructure and technology constraints remain challenges.