April 2024 in “International journal of research in dermatology” Azathioprine can cause hair loss and matted hair.
8 citations
,
June 2012 in “PloS one” Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.
12 citations
,
January 2023 in “Current Oncology” Early detection and complete surgical removal are crucial for better outcomes in treating pilomatrix carcinoma.
January 2022 in “Nasza Dermatologia Online” Dermoscopy helps doctors recognize a type of benign skin tumor called pilomatricoma.
August 2025 in “Dermatopathology” This literature review and case report explore the occurrence of pilomatricomas, benign tumors from hair follicle matrix cells, in syndromic contexts, particularly highlighting a novel association with Apert syndrome. A systematic review of 81 full-text articles identified 96 cases of pilomatricomas linked to genetic syndromes, with a slight female predominance and frequent occurrence in pediatric patients. The study emphasizes the importance of genetic analysis for accurate diagnosis and management, as pilomatricomas can be the first sign of underlying genetic syndromes. Notably, no reports exist of Apert syndrome patients without pilomatricomas, underscoring the significance of this association.