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research Sublingual Minoxidil Increases Fibre Diameter in Male Androgenetic Alopecia. - A proxy for Reversal of Hair Follicle Miniaturization.

January 2025 in “PubMed”

In this randomized, controlled trial, the researchers observed that sub-lingual minoxidil at doses of 1.35 mg and 4.05 mg, but not 0.45 mg, significantly increased hair fibre diameter in men with male androgenetic alopecia over 24 weeks, suggesting a dose-dependent reversal of follicle miniaturization.

research Hair Follicle Transcriptome Analysis Reveals Differentially Expressed Genes That Regulate Wool Fiber Diameter in Angora Rabbits

3 citations , March 2023 in “Biology”

This study identified 2574 differentially expressed genes in the hair follicles of Wan strain Angora rabbits, suggesting that these genes may influence wool fiber diameter and quality.

research Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits

March 2024 in “International journal of molecular sciences”

In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.

research Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter

30 citations , March 2019 in “Archives animal breeding/Archiv für Tierzucht”

In this study, variation in the KRTAP15-1 gene in goats was linked to changes in cashmere fibre diameter, with specific variants showing dominant or recessive effects.

research Discovery of genes and proteins possibly regulating mean wool fibre diameter using cDNA microarray and proteomic approaches

6 citations , May 2020 in “Scientific reports”

In this study, microarray and proteomic analyses indicated that genes involved in immune response, receptor binding, and growth factor activity might influence wool fibre diameter in sheep.

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community How much DHT causes hair loss ?

in Finasteride/Dutasteride 2 upvotes 10 months ago

The user is taking 2.5 mg dutasteride and 5% minoxidil but is not seeing hair regrowth, and is considering adding RU58841. They are experiencing fatigue and low MCV/MCH, possibly related to dutasteride, and are advised to be patient, consider microneedling, and check for iron deficiency.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

129 upvotes 3 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Pelage have made a new post about PP405

in Chat 17 upvotes 1 month ago

PP405 aims to reactivate hair follicle stem cells to promote hair growth, but its effectiveness is debated. Some users are skeptical, citing past failures of similar treatments and questioning the company's claims.

community LLLT seems like it's at least a solid maintenance tool. Can also provide ok regrowth in AA and MPB. - Pubmed

17 upvotes 8 years ago

Low-Level Laser Therapy (LLLT) is seen as a safe and effective method for maintaining hair and promoting regrowth in androgenetic alopecia (AGA) and male pattern baldness (MPB), with devices like the HairMax LaserComb® and iRestore helmet being popular. Some users and professionals are skeptical about its long-term effectiveness and cost.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

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Learn

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learn Hair Fibers

Do hair fibers wash out easily, or do you need a special shampoo to remove them? There is no published trial comparing shampoos for removing hair fibers. Because the fibers cling by static rather than bonding chemically, and because users consistently report they rinse out with ordinary shampoo, the specialist fiber-removal shampoos do not appear to be necessary; a clarifying shampoo may help when fibers are layered under hairspray or gel.

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