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research Cyclosporin inhibits the apoptosis and effects the mRNA expressions of selected growth factors in cultured mouse hair follicles

January 2003 in “Journal of Clinical Dermatology”

This study found that cyclosporin A stimulated hair growth in mouse vibrissae follicles by promoting cell proliferation, reducing apoptosis, and altering the expression of certain growth factor mRNAs.

research Effect of oleuropein on mRNA and protein expression of growth factors in C57BL/6N mouse skin tissue.

December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)”

This source provides procedural details without reporting new experimental findings or conclusions.

research Synthesis of nerve growth factor mRNA in cultures of developing mouse whisker pad, a peripheral target tissue of sensory trigeminal neurons.

5 citations , March 1993 in “The Journal of Cell Biology”

This study concluded that the increase in NGF mRNA levels during mouse whisker pad development is influenced by soluble factors produced within the tissue, rather than linked to epidermal differentiation.

research Expression of Growth Factor mRNA in Hair Follicles Cultured with Some Chinese Herbs

January 2000 in “Chinese Journal of Dermatology”

This study found that the Chinese herb Ligustrum lucidum may enhance expression of hair growth-related genes, HGF and VEGF, in cultured mouse hair follicles.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

In this study, researchers investigated a regulatory network in cashmere goat embryos and found that fibroblast growth factor 10, alongside non-coding RNAs, significantly influences hair follicle cell proliferation, offering insights into the biology of hair follicles in cashmere goats.

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Community Join

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 year ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Can someone please shed some light on natural topicals like castor oil and onion juice

5 upvotes 9 years ago

Castor oil may reduce DHT and help with hair growth, while onion juice lacks evidence for effectiveness. Alternatives to natural topicals include RU58841, olive leaf extract, baicalin, and curcuminoids.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

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Learn

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learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn Epidermal Growth Factor

learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? In mice, VEGF supports hair growth by increasing blood vessels around follicles. There is no direct evidence that raising VEGF treats hair loss in people.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Unproven. Raising VEGF increases vessels around follicles in mice and minoxidil raises VEGF in cultured cells, but no study shows VEGF-marketed products improve scalp blood flow or hair loss in people.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
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learn Platelet-Rich Plasma

What is platelet-derived growth factor beta polypeptide (PDGF-BB), and does it stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Stem Cell Factor

learn KY19382

Experimental compound that activates hair-growth signals, tested only in animals

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