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GlossaryGLP-1 receptor agonists (GLP-1 analogs)

mimic a hormone to regulate blood sugar and promote fullness

GLP-1 receptor agonists are a class of medications that mimic the action of the glucagon-like peptide-1 (GLP-1) hormone, which helps regulate blood sugar levels by enhancing insulin secretion and inhibiting glucagon release. They are commonly used in the treatment of type 2 diabetes and can also promote weight loss by slowing gastric emptying and increasing feelings of fullness.

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research GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects

59 citations , August 2021 in “Frontiers in Endocrinology”

GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.

research Glucagon-Like Peptide-1 Receptor and Proglucagon Expression in Mouse Skin

37 citations , March 2006 in “Regulatory Peptides”

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

research Current Possible Treatment Approaches of Polycystic Ovary Syndrome (PCOS)

February 2024 in “Journal of Education, Health and Sport”

Different treatments for PCOS should be tailored to the individual, including lifestyle changes and various medications.

research Management of Polycystic Ovarian Syndrome: Looking Beyond the Ovaries

April 2024 in “Canadian Women s Health Today”

PCOS treatment focuses on lifestyle changes and specific medications to manage symptoms and complications.

research Obesity in Adults: Position Statement of Various Polish Medical Associations

1 citations , March 2023 in “Nutrients”

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

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community Story time! The Great Unbalding (PP405)

in Research/Science 225 upvotes 2 weeks ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

community PP405 Update and My Take on Pelage

in Research/Science 82 upvotes 1 week ago

Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

community Will PP405 be prohibitively expensive or will it be roughly the same as fin or min?

in Research/Science 6 upvotes 2 months ago

PP405 is expected to be more expensive than finasteride and minoxidil initially due to patent protection, but not as costly as life-saving medications like Ozempic. The price may decrease after the patent expires, but initially, it might be around $100 per month, making it potentially unaffordable for many.

community The amazing fast pace of PP405.

in Chat 322 upvotes 3 weeks ago

PP405 is a new hair loss treatment advancing quickly in trials, generating excitement and skepticism about its effectiveness and marketing claims. Some see it as a potential alternative to minoxidil and finasteride, but concerns about long-term effects and the need for DHT blockers persist.

community Any treatments in development that could theoretically give complete regrowth?

in Research/Science 7 upvotes 5 months ago

New hair loss treatments like PP-405, AMP-303, and SCUBE3 are being discussed, but none are confirmed to fully restore hairlines. Current treatments like Minoxidil, Finasteride, and RU58841 are still widely used, with some hope for future advancements in hair regrowth.

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