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GlossaryDipeptidyl Peptidase-4 Inhibitors (DPP-4 inhibitors)

block the enzyme DPP-4 to help regulate blood sugar

Dipeptidyl Peptidase-4 Inhibitors, often abbreviated as DPP-4 inhibitors, are a class of oral medications used to manage type 2 diabetes. They work by blocking the enzyme DPP-4, which results in increased levels of incretin hormones. These hormones help to regulate blood sugar by increasing insulin release and decreasing glucagon levels, particularly after meals.

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research Women With Polycystic Ovary Syndrome: A Review of Susceptibility to Type 2 Diabetes

January 2023 in “Cureus”

Women with Polycystic Ovary Syndrome (PCOS) have a higher risk of developing type 2 diabetes due to insulin resistance.

research Cardiovascular Profile of Pharmacological Agents Used for the Management of Polycystic Ovary Syndrome

4 citations, January 2019 in “Therapeutic Advances in Endocrinology and Metabolism”

Medications for PCOS don't seem to raise heart disease risk.

research DPP-4 Inhibition with Linagliptin Ameliorates the Progression of Premature Aging in Klotho−/− Mice

20 citations, December 2017 in “Cardiovascular diabetology”

Linagliptin slows down premature aging in certain mice.

research Basic Mechanisms of SARS-CoV-2 Infection: Implications for Endocrine Systems

14 citations, July 2021 in “Reviews in endocrine and metabolic disorders”

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

research Alopecia Universalis After Sitagliptin Intake

2 citations, November 2020 in “Der Hautarzt”

A patient's hair loss may be linked to their diabetes medication, Sitagliptin.

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