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Glossary Genetic Markers

specific DNA sequences indicating genetic traits or disease risks

Genetic markers are specific sequences in the DNA that can be used to identify individuals or species and can be associated with particular traits or diseases. They act like signposts within the genome, helping researchers locate genes linked to conditions such as alopecia, making it easier to study genetic predispositions and develop targeted treatments.

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research Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

81 citations , July 2008 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.

research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

14 citations , January 2018 in “Advances in Clinical Chemistry”

This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.

research Recent omics advances in hair aging biology and hair biomarkers analysis

7 citations , August 2023 in “Ageing Research Reviews”

More research is needed to understand hair aging and develop effective treatments.

research Translational perspectives in HTRA1-associated disorders: biomarkers, gene therapy, and future directions

August 2026 in “International Journal of Pharmaceutical and Clinical Research”

This review synthesizes knowledge on HTRA1-associated disorders, highlighting how mutations in the HTRA1 gene are linked to cerebral small vessel disease and systemic conditions, and discusses emerging diagnostic and therapeutic strategies aimed at precision medicine.

research Genetic prediction of male pattern baldness based on large independent datasets

3 citations , November 2022 in “European Journal of Human Genetics”

This study developed new genetic prediction models for male pattern baldness with improved accuracy by utilizing a large set of markers and independent datasets, making them the most reliable available for this trait.

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community 5 months topical spiro + minox + micro

6 upvotes 1 year ago

A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Iron supplement worked better than Minoxidil. Check your ferritin, even "normal" is low

67 upvotes 1 year ago

Iron supplementation may be more effective than Minoxidil for hair loss. Checking ferritin levels is important, as both low and high levels can affect health.

community Dutasteride thins eyebrows and facial hair but doesn't stop scalp loss.

in Finasteride/Dutasteride 37 upvotes 1 year ago

Dutasteride may not effectively stop scalp hair loss and can cause thinning of facial and body hair, including eyebrows. Users suggest considering other causes like autoimmune conditions or vitamin deficiencies and exploring treatments like finasteride or minoxidil.

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