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research Medical care for children and adolescents with gender dysphoria and gender inconsistency in the light of current recommendations - how to implement the "primum non nocere" principle?

September 2023 in “Fides et Ratio”

This paper reviews the current lack of evidence on the safety and effectiveness of gender-affirming therapies in minors with gender dysphoria, highlighting ethical and legal concerns, including possible long-term consequences such as infertility.

research Research gaps in medical treatment of transgender/nonbinary people

19 citations , February 2021 in “Journal of Clinical Investigation”

This review discusses the challenges and research gaps in transgender health care, highlighting the need for dedicated research infrastructure and funding to develop a more comprehensive evidence base.

research On the effects of testosterone on brain behavioral functions

186 citations , February 2015 in “Frontiers in Neuroscience”

This review discusses the complex effects of testosterone on the brain, emphasizing sex differences, and reports no clinical results; the authors highlight the inconsistencies in current study findings.

research Association of Surgical Risk With Exogenous Hormone Use in Transgender Patients

57 citations , December 2018 in “JAMA Surgery”

This systematic review suggests that current evidence does not support routinely discontinuing gender-affirming hormone treatments before surgery, especially testosterone and spironolactone, due to limited data on related perioperative risks.

research Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?

8 citations , December 2022 in “Nature Reviews Endocrinology”

This review discusses the roles of sex hormones in COVID-19 progression and highlights conflicting evidence on their protective effects and the complexity of sex and gender influences on the disease.

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community New York Magazine article - the Great Unbalding

48 upvotes 1 year ago

PP405, a potential treatment for male pattern baldness, shows promise with some participants experiencing hair regrowth in early trials. However, it is not yet considered a cure and may be used alongside existing treatments like minoxidil and finasteride.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 9 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

community People who don’t experience MPB just have no idea what it’s like.

in Chat 363 upvotes 1 year ago

Hair loss affects self-esteem and mental health, with treatments like finasteride and minoxidil commonly used. People feel misunderstood by those without hair loss and seek more empathy and better treatment options.

community Almost 22M. Finasteride only. A little over a year's worth of progress

in Progress Pictures 383 upvotes 2 years ago

A 22-year-old male shared his one-year progress using finasteride for hair loss, showing significant improvement after 4-6 months. He experienced initial shedding but saw regrowth starting around the 4-month mark.

community Ultimate Stack without nuking your gender (you'll go broke)

86 upvotes 1 year ago

A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

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Learn

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learn Cyproterone

Is cyproterone safe to use during gender transition? Regulators and a large French cohort study link higher-dose, long-term cyproterone acetate to meningioma, and its label also lists liver-enzyme and mood effects — so it is not a drug anyone should call safe in the abstract, and its use in gender-affirming care is a prescriber's decision with monitoring.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Setipiprant

Can Setipiprant be used safely by women or people undergoing gender transition? Setipiprant's safety for women and those in transition is not well-studied.

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