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GlossaryGasdermin A3

protein crucial for hair follicle development and growth

Gasdermin A3 is a protein that plays a crucial role in the regulation of hair follicle development and hair growth. It is part of the gasdermin family, which is involved in cell differentiation and apoptosis (programmed cell death). Mutations or dysregulation of Gasdermin A3 can lead to hair disorders, such as alopecia, where hair loss occurs due to the disruption of normal hair follicle function.

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research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study

1 citations, July 2021 in “Current Issues in Molecular Biology”

Father's finasteride use may affect son's fertility and testicular function.

research Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma

August 2019 in “International journal of dermatology and venereology”

The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations, August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research Gasdermin A3-Mediated Cell Death Causes Niche Collapse and Precocious Activation of Hair Follicle Stem Cells

2 citations, April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting

76 citations, June 2015 in “Journal of biomedical science”

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

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