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Progesterone-Independent Neurosteroid Regulation of Alpha2-GABA-A Receptors in the Hippocampus Subfields

research PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields

14 citations , March 2017 in “Brain research”

This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.

research Ovarian Cycle‐Related Neurosteroid Regulation of GABA‐A Receptor Subunit Plasticity in the Hippocampus Subfields

1 citations , April 2011 in “The FASEB Journal”

This study suggests that the regulation of GABA‐A δ subunit expression by ovarian progesterone-derived neurosteroids may influence seizure susceptibility in catamenial epilepsy.

research Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice

March 2008 in “The FASEB Journal”

This study found that neurosteroid withdrawal significantly increased hippocampal GABA-A receptor α4 subunit expression in female mice, confirming an association between neurosteroid withdrawal and altered receptor expression.

research Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain

12 citations , February 2017 in “Journal of neuroscience research”

This study suggests that extrasynaptic δGABA-A receptors may have a protective role in modulating the severity of catamenial-like seizures by influencing neurosteroid and benzodiazepine responses in mice.

Realizing the Therapeutic Potential of Neuroactive Steroid Modulators of the GABAA Receptor

research Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

40 citations , December 2019 in “Neurobiology of Stress”

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

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Community Join

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community After praising finasteride on this sub for a while I realised it gave me Brain Fog. I think its related to inhibiting GABA and interferring with mirtazapine (an antidepressant).

9 upvotes 6 years ago

Finasteride caused brain fog and reduced the effectiveness of mirtazapine for the user, leading them to stop finasteride and notice improvements in motivation and focus. The user suggests that finasteride might be incompatible with mirtazapine for some people and recommends mirtazapine for those experiencing mental fog from finasteride.

community Do it yourself topical Fin and Min solution works

in Progress Pictures 119 upvotes 1 year ago

A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 9 months ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 1 year ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

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learn Aminobutyric Acid

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