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ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

research ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

161 citations , August 2013 in “Journal of experimental botany”

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

research Natural Products Reverse Cancer Multidrug Resistance

27 citations , March 2024 in “Frontiers in Pharmacology”

Natural products can help overcome cancer drug resistance.

research Role of the Wnt Signaling Pathway in Keratoacanthoma

2 citations , November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

research Epimorphic Regeneration in Mice Is p53-Independent

20 citations , September 2010 in “Cell Cycle”

Mice can regenerate ear tissue without the p53 protein.

research Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy

32 citations , August 2019 in “Nature Communications”

Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

nkrata in Research 461 upvotes 9 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community 10 months on dutasteride. Lost about half of my hair density. Losing 150-250 hairsevery day

in Finasteride/Dutasteride 70 upvotes 1 year ago

User experienced significant hair loss after adding dutasteride to their finasteride and minoxidil regimen. They plan to revert to finasteride only due to lack of improvement.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.