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research Dermal‐Epidermal Cross‐Talk: Differential Interactions With Microvascular Endothelial Cells

6 citations , October 2016 in “Journal of Cellular Physiology”

This study found that human dermal fibroblasts can promote the viability and proliferation of microvascular endothelial cells in vitro, revealing important interactions at play in hair growth.

Effects of the Biomimetic Peptide Sh-Polypeptide 9 (CG-VEGF) on Cocultures of Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

research Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells

7 citations , December 2015 in “Experimental Dermatology”

The study found that Sh-Polypeptide 9, a biomimetic peptide, enhances endothelial tubulogenesis and VEGF production more effectively than minoxidil, particularly at low concentrations, suggesting potential for hair follicle vascularization.

Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

research Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis

1 citations , January 2023 in “Burns and trauma”

This study found that tdDPC-EVs significantly improved wound healing by enhancing angiogenesis through the KLF4/VEGFA axis, offering advantages over traditional DPC-EVs.

Ashwagandha Seed Plant Exosome-Like Nanovesicles Promote In Vitro Cellular Regeneration of Human Dermal Hair Follicle, Endothelial and Fibroblast Cells

research LB1024 Ashwagandha (Withania somnifera) seed plant exosome-like nanovesicles promote in vitro cellular regeneration of human dermal hair follicle, endothelial and fibroblast cells

1 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Ashwagandha-derived nanovesicles increased cell proliferation, angiogenesis, and growth factor expression in vitro, suggesting they may have potential as a plant-based alternative or complement to current therapies for hair and skin conditions.

Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

research Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway

June 2023 in “Italian Journal of Medicine”

This study found that urotensin II promoted proliferation and VEGF secretion in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway, with the effect being reversible by a Wnt inhibitor.

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community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Someone please offer reassurance

in Minoxidil 3 upvotes 1 month ago

A 19-year-old male is experiencing hair shedding while using oral minoxidil, ketoconazole, dermastamping, and saw palmetto, and is considering switching to finasteride for better results. Users suggest that saw palmetto may not be effective and recommend finasteride instead, while also discussing other treatments like rosemary oil, peppermint oil, and pumpkin seed oil.

community GH peptides + KLOW blend saved my hair. before and after pics.

833 upvotes 5 months ago

Using finasteride and peptides, including GHK-Cu, improved hair thickness and regrowth. The user also used a KLOW blend and CJC/IPA for better sleep and recovery.

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