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GlossaryCorticotropin-Releasing Hormone

peptide hormone that triggers stress response via ACTH release

Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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research Does the Corticotropin-Releasing Hormone System Play a Role in the Pathogenesis of Lichen Planus?

January 2017 in “Postepy Dermatologii I Alergologii”

The CRH/CRH-R1 system might be involved in causing lichen planus.

research Corticotropin-Releasing Hormone and the Skin

137 citations, January 2006 in “Frontiers in bioscience”

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

research New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

12 citations, April 2020 in “British Journal of Dermatology”

Caffeine may help reduce stress-induced hair loss.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations, June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

98 citations, July 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

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community How does hair loss and recovery work?

in Chat 12 upvotes 3 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.