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GlossaryIntermediate Filaments

structural proteins in cells providing mechanical support and stability

Intermediate filaments are a type of structural protein found within cells that help maintain their shape and integrity. They are part of the cytoskeleton, which also includes microtubules and actin filaments, and they provide mechanical support to cells, enabling them to withstand stress and strain.

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community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 5 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Anti Fibrosis and Calcification regimen?

in Question 10 upvotes 6 years ago

The user experienced no improvement in hair loss with finasteride and minoxidil but had side effects. They plan to add wounding, scalp massage, vitamin K, and taurine supplements to their regimen and seek feedback on these additions.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community 7 months update - 1 mg fin, topical min

in Progress Pictures 736 upvotes 1 year ago

A user's 7-month progress using 1 mg finasteride and topical minoxidil, with no side effects from the finasteride, achieving baby hairs on the hairline and other positive results. Other users have discussed different treatments such as microneedling and supplements, providing advice and encouragement to the poster.

community Why I really believe the tension theory is the cause of MPB

in Research/Science 70 upvotes 3 years ago

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

community My hair loss recovery (9 months treatment), androgenic alopecia

in Progress Pictures 731 upvotes 10 months ago

A user shared a 9-month hair recovery journey from androgenic alopecia using 1 mg finasteride daily, 5% minoxidil twice daily, and weekly dermarolling with a 1.5 mm roller. Some responders were skeptical about the authenticity of the results, while others confirmed the consistency of the user's appearance and supported the effectiveness of the treatment.

community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 6 months ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 1 year ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community (M22) Finasteride didn’t stop my hair loss. Looks like I’ve lost the fight against MPB.

in Progress Pictures 21 upvotes 1 year ago

User started finasteride at 18, added minoxidil later but stopped due to side effects. Hair loss continued despite treatments, considering dutasteride but hesitant. Others suggest trying dutasteride and discussing with a dermatologist.

community For what it's worth, I just want to state that I also think that adding Dutasteride to Finasteride has made my hair worse

in Finasteride/Dutasteride 18 upvotes 3 years ago

A user shared that adding Dutasteride to Finasteride worsened their hair loss, despite initial improvements with Finasteride alone. Others in the conversation debated the effectiveness of Dutasteride, with some suggesting individual responses vary and others defending its proven efficacy for hair loss.

community If finasteride gives you sides… try Dutasteride

in Finasteride/Dutasteride 7 upvotes 2 months ago

The user experienced severe side effects from finasteride but found success with Dutasteride, minoxidil, microneedling, and ketoconazole shampoo. They recommend trying Dutasteride if finasteride causes issues.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Happily nuking my DHT and hairloss to oblivion.

in Finasteride/Dutasteride 79 upvotes 1 year ago

The effectiveness of Finasteride/Dutasteride for treating hair loss, and a cautionary tale about potential side effects such as gynecomastia.

community [AMA] 5-Month Progress Report: Dutasteride and Oral Minoxidil Results.

in Minoxidil 73 upvotes 3 years ago

Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.

community Extreme hair and beard growth from Stemoxydine. Big 3 + 1?

in Product 23 upvotes 3 years ago

Using a combination of Stemoxydine, minoxidil, dutasteride, and keto shampoo to achieve extreme hair and beard growth. The user has experienced positive results with terminal hairs at the hairline and an increase in density to their stubble after several weeks of use.

community Why you should use 0.5mg Dut instead of 1mg Fin

in Finasteride/Dutasteride 45 upvotes 2 years ago

The comparison of 0.5mg dutasteride and 1mg finasteride for treating hair loss in men with androgenetic alopecia, with discussion of which is more effective and has fewer side effects.

community For Once and For All: Is It the DHT in the Scalp That Matters, Not the DHT in Your Bloodstream?

in Treatment 84 upvotes 2 months ago

DHT in the scalp, not the bloodstream, is crucial for hair loss. Treatments discussed include finasteride, minoxidil, dutasteride, and microneedling.

community Topical Dutasteride is Here.

in Finasteride/Dutasteride 153 upvotes 3 years ago

The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

23 upvotes 6 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community [M19] five months progress on fin+ oral minoxidil

in Progress Pictures 34 upvotes 1 year ago

User reports five months progress on finasteride and oral minoxidil, with thicker hair and no visible scalp. Started at 2.50mg and increased to 10mg without side effects.

community Hey /r/ Tressless, thought it would be interesting to take a full journey of hair restoration with you! DAY 1825

in Finasteride/Dutasteride 18 upvotes 4 years ago

The efficacy of various hair loss treatments, including Finasteride and Dutasteride, with personal anecdotal evidence about potential side effects. It also includes advice to get a male hormone blood panel done before starting treatment, and lifestyle changes to minimize side effects.

community Research-Backed Dutasteride Simulator

in Research 341 upvotes 1 day ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community 26 Months of Treatment (Min/Fin/Micro) …

in Progress Pictures 344 upvotes 7 months ago

The conversation is about a user's 26-month hair loss treatment journey using finasteride, minoxidil foam, and microneedling, with gradual improvement in their hairline. The user applied treatments consistently and adjusted the frequency of microneedling based on feedback, noting that progress can feel slow compared to others.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 8 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Progress of 2 months on minoxidil, zinc, and biotin plus Dermaroll once a week. Minox definitely works even without fin!

16 upvotes 4 years ago

User reports progress in 2 months using minoxidil, zinc, biotin, and weekly dermarolling. Minoxidil shows effectiveness even without finasteride.

community Since Dutasteride is dose dependent, is there any real difference in taking 0.5mg daily vs every other day?

in Finasteride/Dutasteride 16 upvotes 1 month ago

Taking dutasteride daily at higher doses results in more effective DHT suppression compared to every other day dosing, due to its dose-dependent nature and long half-life. Even at lower doses, dutasteride is more effective than finasteride for hair loss.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 6 months ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community Do some people respond better to finasteride than dutasteride? Or the other way around?

in Finasteride/Dutasteride 20 upvotes 1 year ago

The post and conversation are about the effectiveness of finasteride and dutasteride for hair loss. The conclusion is that the user had better results with finasteride and experienced rapid balding after switching to dutasteride.