Search

for
Search:

Did you mean Gonadotropin-releasing hormone?

Glossary Gonadotropin-releasing hormone

regulates release of reproductive hormones from the pituitary gland

Gonadotropin-releasing hormone (GnRH) is a key hormone produced in the hypothalamus of the brain. It regulates the release of two other important hormones from the pituitary gland: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are crucial for reproductive function, including the development of eggs in ovaries and sperm in testes.

Related Terms

Sort by

Community Join

30 / 1000+ results

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

114 upvotes 3 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community My Estradiol Level on Finasteride

18 upvotes 1 year ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community [Research] RU-58841/Pyrilutamide and impacts on male fertility

6 upvotes 2 years ago

The drugs RU-58841, Pyrilutamide (KX-826), Apalutamide, Enzalutamide, and Darolutamide, which are nonsteroidal antiandrogens (NSAA), potentially impacting male fertility. Pyrilutamide, similar to Enzalutamide, may have reversible effects on fertility.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 year ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community How is the GT20029 different to pyrilutamide as an androgenic antagonist

1 year ago

GT20029 and pyrilutamide are both androgen antagonists but work differently; GT20029 degrades the androgen receptor, while pyrilutamide blocks DHT from binding. GT20029 is expected to have similar efficacy to CosmeRNA.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community Any other non-responders to most medications?

6 upvotes 3 years ago

The user has not seen results from various hair loss treatments including finasteride, dutasteride, minoxidil, and others over several years and is considering adding RU58841 and starting hormone replacement therapy. They are also experiencing anxiety and contemplating moving to a more accepting environment for their nonbinary identity.

community Consenus on Kx-826/pyrilutamide vs ru58841

11 upvotes 1 week ago

KX-826 is considered effective for hair maintenance, with better safety research than RU58841, but lacks positive anecdotes. RU58841 is seen as potentially stronger, but concerns exist about systemic effects; combining anti-androgens with 5AR inhibitors is suggested for better results.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 14 upvotes 1 year ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Does anyone have any experience with Estradiol, Cyproterone Acetate, Spironolactone, Bicalutamide ?

4 upvotes 6 years ago

Some users have experienced good hair regrowth with estradiol, cyproterone acetate, spironolactone, and bicalutamide, but these treatments may cause feminization and other side effects. It's advised to consult a doctor before using these treatments, as they can lower testosterone and have significant risks.

community Ru-58841 or KX-826 (Pyrilutamide)?

12 upvotes 3 years ago

Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community Pyrilutamide/KX-826 for women?

in Treatment 1 upvotes 1 year ago

Pyrilutamide/KX-826 is being considered as a potential treatment for female androgenetic alopecia (AGA), but its high cost and limited data on effectiveness are concerns. Kintor markets it for both men and women.

community Anyone know by what percentage Pyrilutamide or Ru decrease your androgens?

in Chat 1 upvotes 1 year ago

Pyrilutamide and RU58841 are androgen receptor antagonists that block receptors without significantly reducing testosterone or DHT levels. Any indirect effect on androgen levels is likely negligible.

community Best available SARD right now?

in Treatment 3 upvotes 4 months ago

The user is considering RU58841 and has been using dutasteride since age 17. They are seeking affordable SARD options, mentioning ASC-J9, GT20029, and AH001.

community Estradiol mesotherapy / idea feedback

5 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

8 upvotes 10 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Need supplemental products in addition to oral minoxidil and oral dutasteride

1 upvotes 1 year ago

The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

community Experiences of regrowth on HRT

14 upvotes 3 days ago

A 23-year-old is experiencing hair loss and is using a regimen including topical Minoxidil, finasteride, spironolactone, and Estradiol gel as part of hormone replacement therapy (HRT). They are hopeful for hair regrowth and are considering using a micro needler, with others suggesting that their current treatment could lead to significant improvement.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Not sure what else to do, can’t use anti-androgens (Baseline Hormonal Bloodwork included) need advice badly

6 upvotes 5 years ago

User experienced feminizing side effects from finasteride and tried RU, alfatradiol, and finasteride without success. They are now considering treatments like Stemoxydine, Zix, Minoxidil, Dermarolling, Eucapil, and a hair transplant.

community Ru-58841 vs KX-826/pyrilutamide while on steroids

4 upvotes 1 year ago

The user increased their steroid dosage and noticed hair shedding, so they adjusted their regimen by reducing steroid doses and adding oral dutasteride. They are also experimenting with combining RU-58841 and KX-826/pyrilutamide in minoxidil to address hair loss.

community Anti-androgens - resist hair loss, but inhibit hair regrowth?

1 upvotes 2 years ago

Blocking androgen receptors may prevent hair loss but also inhibit hair regrowth. Anti-androgens like RU58841 and pyrilutamide slow hair loss but show minimal regrowth.

community GT20029. Kintor Pharma’s Product

12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Pyrilutamide and tretinoin/retinoic acid? (minoxidil max duagen products)

1 upvotes 3 years ago

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

5 upvotes 2 years ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Seeking advice from dut non-responders who used RU

in Update 1 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically the use of RU58841 by individuals who did not respond to dutasteride. Users share experiences with maintaining hair using RU58841 and mention trying pyrilutamide and the upcoming availability of pp405.

community What are the alternatives to spironolactone for AGA?

7 upvotes 1 year ago

The user experienced side effects from spironolactone and is seeking alternatives for androgenetic alopecia (AGA), considering saw palmetto but unsure of its effectiveness. They are also exploring the possibility of using topical spironolactone, despite availability challenges.

community Research behind RU-58642? Has anyone heard of this?

in Research/Science 1 upvotes 1 year ago

RU-58642 is a powerful anti-androgen that was not developed further, possibly due to safety concerns or financial reasons. RU58841 is a topical alternative, but it is less effective than finasteride and dutasteride, and its long-term effects are not well-studied.

community 2 years on treatment (stack update)

465 upvotes 1 year ago

A user shared their hair regrowth progress using Dutasteride, topical Minoxidil, Spironolactone, and Estradiol Valerate injections as part of hormone replacement therapy for transitioning. They experienced significant hair improvement and personal satisfaction but caution against this approach for non-transitioning individuals due to irreversible changes.