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Did you mean Estrogen Receptors?

Glossary Estrogen Receptors

proteins that bind estrogen, influencing cell behavior and function

Estrogen receptors (ER) are proteins found inside and on the surface of certain cells that bind to the hormone estrogen. When estrogen binds to these receptors, it can influence the behavior of the cell, including growth, differentiation, and function. These receptors play a crucial role in various physiological processes, including reproductive health, bone density, and even hair growth. In medical research, ERs are significant in understanding conditions like breast cancer, where the presence of these receptors can influence treatment options.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Someone told me it is the increase in estradiol and estrogen from more free t that makes dht blockers work?

6 months ago

Finasteride and its effects on hair loss, with discussions on the role of estradiol and estrogen. Users debate whether increased estrogen from DHT blockers contributes to hair regrowth, with concerns about potential side effects like chemical castration.

community Dose of oral spironolactone for males to stop hairloss when 5ari blockers not working, any idea

8 upvotes 5 months ago

The conversation discusses using oral spironolactone for hair loss in males when 5ari blockers fail. Concerns are raised about spironolactone's side effects, and alternatives like pyrilutamide and breezula are suggested.

community Injecting estrogen for hairline regrow

268 upvotes 1 year ago

A user plans to undergo a temporary MtF transformation to regrow hair, using estrogen, RU58841, and Dutasteride, then revert with testosterone. Many users criticize the plan, suggesting alternatives like hair transplants, and emphasize that estrogen is not a reliable solution for hair regrowth.

community I really hate how current hair loss treatment only rely on DHT blockers

in Finasteride/Dutasteride 76 upvotes 2 years ago

The conversation discusses dissatisfaction with current hair loss treatments that mainly focus on DHT blockers like finasteride and dutasteride. Alternative treatments mentioned include RU58841, pyrilutamide, minoxidil, rosemary oil, and future possibilities like hair cloning.

community Bicalutamide effect on androgens?

5 upvotes 5 years ago

Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.

community If you're worried that you're beginning to develop gyno on fin...

32 upvotes 3 months ago

Finasteride can cause gynecomastia due to increased estrogen from reduced DHT conversion, which some users manage by losing weight and taking supplements like DIM and calcium D-glucarate. Users discuss various experiences with finasteride, dutasteride, and minoxidil, noting side effects and strategies to mitigate them, including switching medications and considering surgery.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community Hair regrow idea: High dose Testosterone + RU58841

in Satire 2 upvotes 4 months ago

Using high doses of testosterone with RU58841 to create an androgen-free environment for hair regrowth is suggested, but concerns about heart health and the effectiveness of this approach are raised. Alternatives like topical estrogen, progesterone, and other treatments like finasteride and dutasteride are discussed.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Fin alternative? (27M) Norwood 3

4 upvotes 6 years ago

A 27-year-old male experiencing hair loss at Norwood 3 level has tried minoxidil and finasteride but stopped finasteride due to side effects. He is exploring alternatives like Dermapen, Regenepure DR Shampoo, saw palmetto, and considering aromatase inhibitors for managing side effects, while also seeking advice on DHT blockers.

community The Ultimate Guide to growing your hair back (revised).

in Treatment 161 upvotes 1 year ago

Hair loss treatments include using finasteride, dutasteride, and RU58841. Lifestyle changes like increasing carb intake and moderate alcohol consumption are suggested to boost estrogen levels.

community Why is Minoxidil not enough for hair loss? (No fin)

59 upvotes 1 year ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

371 upvotes 8 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community ultimate nuclear stack? need more suggestions bruhh

in Technology 2 upvotes 1 year ago

The conversation discusses an extensive hair loss treatment regimen including dutasteride, GT20029, RU58841, pyrilutamide, minoxidil, microneedling, ketoconazole shampoo, and experimental compounds. The user humorously describes their approach as a comprehensive strategy to combat hair loss while maintaining hair growth.

community Progress photos from May 9 2024 until today.

40 upvotes 1 year ago

OP uses microneedling, Minoxidil, and recently started RU58841 for hair loss. Users suggest adding finasteride, but OP is concerned about side effects.

community Wouldn’t this nuclear stack make it almost impossible to lose hair?

67 upvotes 1 year ago

The conversation discusses a hair loss treatment regimen involving dutasteride, pyrilutamide, oral minoxidil, and microneedling, with the aim of suppressing DHT and stimulating hair growth. Users debate the effectiveness and potential side effects of these treatments, noting that individual results may vary and that no treatment is foolproof.

community My hormone levels after 2 months of Finasteride and 2 weeks of Dutasteride

12 upvotes 3 weeks ago

The conversation discusses elevated hormone levels after using Finasteride for 2 months and Dutasteride for 2 weeks for hair loss. Users suggest that increased testosterone and estradiol levels are expected due to DHT inhibition, and it's not a concern unless symptoms occur.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Joined the Dutasteride Master Race

586 upvotes 1 year ago

Dutasteride and finasteride are discussed for hair loss treatment, with users sharing experiences and debating their effectiveness and side effects. Celebrities are noted as common users, and there is debate over which treatment is superior.

community Having AGA as a girl makes me depressed

65 upvotes 7 months ago

A 20-year-old woman with androgenetic alopecia feels depressed about her hair loss, despite using topical minoxidil, spironolactone, and saw palmetto. Suggestions include trying oral minoxidil, higher doses of finasteride or dutasteride, and checking for vitamin deficiencies and heavy metal exposure.

community hairloss treatment, what to expect (bloodwork)

1 upvotes 11 months ago

The conversation discusses hair loss treatment options, focusing on finasteride and its potential effects on gynecomastia. The user is considering finasteride while managing hormone levels with supplements like boron, vitamin D, zinc, magnesium, and P5P, and is advised to consult an endocrinologist for further evaluation.

community What can be the real reason of Finasteride SE ?

18 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

community What happened to topical dutasteride??

in Finasteride/Dutasteride 28 upvotes 1 year ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 1 year ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

community Fin for 7 months and my sclap is now transparent

in Progress Pictures 16 upvotes 6 months ago

A 24-year-old male has been using finasteride for 7 months and noticed thinning hair, especially when wet, and is concerned about the effectiveness of the treatment. Suggestions include continuing finasteride, considering minoxidil, and possibly trying micro-needling.

community I’m considering stopping finasteride

in Finasteride/Dutasteride 157 upvotes 8 months ago

The user is considering stopping finasteride due to depression, anxiety, and difficulty building muscle, despite its effectiveness in stopping hair loss. Suggestions include reducing the dose, switching to topical solutions, or consulting a doctor for alternatives like dutasteride or RU58841.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 1 year ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

community How to Keep Your Hair on Steroids

25 upvotes 2 years ago

To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.