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research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.

research Cell Kinetics of Anagen Scalp Hairs under Physiological and Pathological Conditions

5 citations , March 2009 in “Skin Pharmacology and Physiology”

This study found that DNA flow cytometry effectively evaluates physiological and hormonal influences on cell cycle kinetics of human anagen hair bulbs, with increased S phase cells observed in male pattern baldness, hirsutism, and hyperthyroidism.

Faculty Opinions Recommendation of Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

research Faculty Opinions recommendation of Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration.

December 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The conclusion is that the dermal papilla is crucial for hair follicle regrowth, and hair follicles undergo significant structural changes in addition to cell division during regeneration.

Photobiomodulation of Human Dermal Fibroblasts In Vitro: Decisive Role of Cell Culture Conditions and Treatment Protocols on Experimental Outcome

research Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome

39 citations , June 2017 in “Scientific Reports”

Different lab conditions and light treatment methods change how human skin cells respond to light therapy.

research The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells

48 citations , April 2021 in “Pharmaceuticals”

This study found that curcumin encapsulated in liposomes enhanced photodynamic therapy's effectiveness against skin cancer cells while reducing toxicity to normal human keratinocytes.

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Community Join

5 / 664 results

community Do none pharmaceutical treatments also work?

5 upvotes 3 months ago

Topical finasteride and Minoxidil are the most effective treatments for hair loss, with non-pharmaceutical options like PRP, stem cell therapy, and red light caps offering minimal additional benefits. Users suggest sticking to proven treatments unless cost is not a concern.

community Kintor Pharma Announces Completion of First Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China.

132 upvotes 3 years ago

Kintor Pharma has started a Phase II trial in China for GT20029, a potential new treatment for hair loss. Participants are discussing the significance, potential release dates, and comparing it to other treatments and technologies like stem cell hair transplants and SAMIRNA.

community Recent trials investigating mesenchymal stem cell derived exosomes demonstrate significant increases in anagen duration and hair shaft caliber by upregulating Wnt/beta-catenin pathways.

4 upvotes 3 weeks ago

Exosomes from mesenchymal stem cells can increase hair growth by enhancing anagen duration and hair shaft thickness through the Wnt/beta-catenin pathway. Phase 2 trials show improved hair counts over 24 weeks.

community My summation of PP405 - looks promising

210 upvotes 1 year ago

PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 10 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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Learn

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learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.
How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.
Are stem cell factor products safe for long-term scalp use? Stem cell factor products lack proven long-term safety for scalp use.
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learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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Clinics

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Experts

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