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research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

248 citations , November 2011 in “The EMBO Journal”

This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

44 citations , March 2015 in “PLOS ONE”

This study found that FGF-9 treatment in diabetic mice improved heart function after myocardial infarction by decreasing monocyte infiltration and promoting anti-inflammatory macrophage differentiation.

research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair: Wnt1/βcatenin injury response regulates cardiac repair

1 citations , November 2020

This study found that a pro-fibrotic Wnt1/βcatenin injury response is crucial for maintaining cardiac function following acute ischaemic cardiac injury by activating the epicardium and cardiac fibroblasts.

Cthrc1 Deficiency Aggravates Wound Healing and Promotes Cardiac Rupture After Myocardial Infarction via Non-Canonical WNT5A Signaling Pathway

research Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway

9 citations , January 2023 in “International Journal of Biological Sciences”

This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

This study observed that isoproterenol directs hair-follicle-associated pluripotent stem cells to differentiate into cardiac muscle cells in large numbers, forming tissue sheets of beating heart muscle cells in culture.

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community Anyone read oral minoxidil's leaflet?

4 upvotes 1 year ago

Oral minoxidil is discussed, highlighting potential cardiovascular risks at high doses, but users note that lower doses commonly used for hair loss are generally considered safe. Monitoring by doctors is advised, and some users report taking it without issues, comparing its risks to those of common medications like ibuprofen.

community I experienced severe cardiac and renal side effects with only 1.25 mg of minoxidil

942 upvotes 2 weeks ago

A 26-year-old male experienced severe cardiac and renal side effects, including heart palpitations and bigeminy, after taking a single 1.25 mg dose of oral minoxidil. Despite skepticism from others, medical tests confirmed these symptoms were linked to the medication.

community The dose dependent nature of the cardiac effects RU58841

5 upvotes 8 months ago

Reducing the dose of RU58841 from 25mg to 7.5mg topically helped minimize heart palpitations. Users discussed the cardiac effects of RU58841 and minoxidil, noting that no treatment is completely free of side effects.

community The Biggest Concern That I Have For Oral Minoxidil: Cardiac Hypertrophy

26 upvotes 3 years ago

Oral minoxidil can cause serious heart issues like cardiac hypertrophy and arrhythmias, prompting some users to reduce dosage or switch to topical treatments. Despite significant hair regrowth, side effects such as shortness of breath and chest pains are common concerns.

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