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Glossary Carcinomas

Carcinomas are a type of cancer that originates in epithelial cells, which line the surfaces of organs and structures throughout the body. While not directly related to hair loss, certain carcinomas, particularly those affecting the scalp or skin, can lead to hair loss due to localized treatments like radiation or surgical removal. Additionally, some systemic treatments for cancer, such as chemotherapy, can cause widespread hair thinning or loss as a side effect. Understanding carcinomas is important in the context of hair biology, as they can impact the health of hair follicles and the scalp environment.

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research THE HAIR CYCLE OF THE MOUSE AND ITS IMPORTANCE IN THE STUDY OF SEQUENCES OF EXPERIMENTAL CARCINOGENESIS

111 citations , March 1951 in “Annals of the New York Academy of Sciences”

This article discusses the hair cycle of mice and its relevance in studying experimental carcinogenesis sequences, but it reports no new research findings.

research Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

99 citations , February 2000 in “PubMed”

This study found that overexpression of PKCepsilon in transgenic mice reduced papilloma development but accelerated carcinoma formation in a skin tumor promotion model.

research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

70 citations , December 2008 in “Cancer Research”

This study found that activating CXCR2 on ras-transformed keratinocytes promotes migration and tumor development in a mouse skin model.

research WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

55 citations , March 2015 in “Carcinogenesis”

This study found that WNT10A is significantly upregulated in human esophageal squamous cell carcinoma and is associated with enhanced tumor cell migration, invasion, and poor survival.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

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