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GlossaryTriazole Antifungal

inhibit fungal cell membrane synthesis by targeting specific enzymes

Triazole antifungals are a class of medications used to treat fungal infections. They work by inhibiting an enzyme called lanosterol 14α-demethylase, which is crucial for the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption weakens the fungal cell membrane, leading to the death of the fungus. Common examples include fluconazole and itraconazole.

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research Itraconazole in the Treatment of Acute and Recurrent Vulvovaginal Candidosis: Comparison of a 1-Day and a 3-Day Regimen

12 citations, April 2005 in “Mycoses”

A 1-day or 3-day itraconazole treatment is effective for acute vulvovaginal candidosis, but recurrent cases may need longer treatment.

research Follicles, Fungi, And Scalp Conditions

1 citations, September 2011 in “British Journal of Dermatology”

Malassezia yeast plays a key role in dandruff and seborrhoeic dermatitis.

research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

90 citations, May 2019 in “Drugs”

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

research In Vitro and In Vivo Assessment of Metabolic Drug Interaction Potential of Dutasteride with Ketoconazole

7 citations, December 2019 in “Pharmaceutics”

Taking Dutasteride with Ketoconazole can increase Dutasteride's effects and side effects.

research Novel Micelle Formulations to Increase Cutaneous Bioavailability of Azole Antifungals

109 citations, March 2011 in “Journal of controlled release”

New micelle solutions greatly improve skin delivery of certain antifungal drugs.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community 3 month progress; 1mg Oral Fin, 2.5mg Oral Min, nizoral ×3 week, 1.5mm derma 1x week. Same hair length... hoping it can recover some more.

in Progress Pictures 334 upvotes 1 year ago

User shares 3-month hair loss treatment progress using 1mg oral Fin, 2.5mg oral Min, Nizoral 3x week, and 1.5mm derma 1x week. Others comment on improvements and ask about oral Min source.

community Keto 2% halted my insane shed immediately

in Ketoconazole 56 upvotes 11 months ago

Ketoconazole 2% shampoo stopped a user's severe hair shedding after just two uses, a result not achieved by finasteride or oral minoxidil. Some users suggest the shampoo's anti-androgenic properties may help with hair loss, while others think the shedding might have stopped naturally or due to the end of a shedding phase.

community Clotrimazole a better anti-androgen than Ketoconazole?

in Research/Science 1 upvotes 4 years ago

Clotrimazole may inhibit testosterone better than Ketoconazole. The user considers applying Clotrimazole cream on the scalp for hair loss.

community The New, Improved CB-03-01/Setipiprant Group Buy

29 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.