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Glossary Autoimmune Diseases

immune system attacks the body's own tissues

Autoimmune diseases are conditions where the immune system mistakenly attacks the body's own tissues, thinking they are foreign invaders. This can lead to a variety of health issues, depending on which part of the body is targeted. Examples include rheumatoid arthritis, where joints are affected, and alopecia areata, where hair follicles are attacked, leading to hair loss.

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Research

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research “Downy hair sign”—A clue to autoimmune disease in curly hair

July 2024 in “JAAD Case Reports”

This study reported three cases where patients experienced changes in hair curl patterns after acute lupus alopecia and alopecia areata, with baseline hair texture restored following medical treatment.

Alopecia in Preexisting Autoimmune Thyroid Disease in Family Medicine Practice: Can Hyperprolactinemia Induce Hair Loss? A Case Report

research Alopecia in preexisting autoimmune thyroid disease in family medicine practice: can hyperprolactinemia induce hair loss? A case report

1 citations , January 2021 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

This report suggests a potential link between hyperprolactinemia and alopecia in women with autoimmune thyroid disease and emphasizes the importance of considering other causes in diagnosis.

research Alopecia Areata: A tissue specific autoimmune disease of the hair follicle

185 citations , August 2005 in “Autoimmunity Reviews”

This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.

research Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice

18 citations , April 2013 in “PLOS ONE”

This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.

research Autoimmune Disease and Hair Loss

35 citations , October 2012 in “Dermatologic Clinics”

This article reviews the impact of different forms of alopecia on patients with systemic autoimmune diseases and reports no new clinical findings; it emphasizes the need for attentive management of alopecia-related symptoms.

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Community Join

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community Alcohol consumption triggering sheds.

4 upvotes 4 years ago

Alcohol consumption can trigger hair shedding and affect hair treatment effectiveness, especially in those with autoimmune diseases. Treatments mentioned include RU58841, oral minoxidil, and stemoxydine, with finasteride also noted by another user.

community Vitamin E and K deficiency (F,25)

in Research/Science 3 upvotes 4 months ago

Vitamin E and K deficiencies due to exocrine pancreatic insufficiency may affect hair growth. A scalp biopsy is recommended to check for autoimmune-related hair loss.

community My hairline has started to grow back since I have been taking iron/zinc vitamins

in Chat 9 upvotes 8 months ago

Iron and zinc vitamins helped improve hairline regrowth for someone with celiac disease. Nutrient deficiencies, like iron, can contribute to hair loss, especially around the temples.

community Not everyone should immediately go on Fin if they are starting to bald

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.

community fin 0.5 mg everday 6 months update

in Finasteride/Dutasteride 28 upvotes 2 years ago

The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Overview

learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Tofacitinib

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.
What are the key limitations and considerations surrounding tofacitinib in hair loss products and therapies? Reported hair regrowth with tofacitinib comes from alopecia areata, an autoimmune condition — mostly from small, non-randomized studies, with relapse common after stopping. There is no good evidence it helps pattern hair loss, and it is not approved for hair loss anywhere.

learn Scalp Micropigmentation

Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.

learn Baricitinib

Baricitinib: How did a drug for arthritis end up helping people regrow hair from alopecia areata? Baricitinib helps regrow hair by targeting the autoimmune response in alopecia areata.

learn Salicylic acid

What makes alopecia areata different from other types of hair loss, and can topical Salicylic acid treatments help regrow the affected areas? Alopecia areata is an autoimmune condition, and salicylic acid does not promote hair regrowth.

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Clinics

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas