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December 1997 in “Calcified Tissue International”
Higher androgen levels and site-specific ARexpression cause sex-related skeletal differences, and certain steroids can boost ARexpression and androgen effects in bone cells.
The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.
Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.
Hair loss treatments include using finasteride, dutasteride, and RU58841. Lifestyle changes like increasing carb intake and moderate alcohol consumption are suggested to boost estrogen levels.
Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.