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Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients With or Without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1

research Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients with or without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1

January 2023 in “Annals of Dermatology”

This study found that alopecia areata patients with a CCHCR1 gene variant had higher recurrence rates and structural abnormalities in hair compared to those without the variant.

Alpha-1 Adrenergic Receptor Agonist Induced Piloerection Protects Against the Development of Traction Alopecia

research 556 α 1 -AR agonist induced piloerection protects against the development of traction alopecia

April 2016 in “Journal of Investigative Dermatology”

This study found that topical phenylephrine, an α1-AR agonist, significantly reduced hair shedding and increased epilation force threshold in women experiencing traction alopecia during cosmetic procedures.

research Minoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells

16 citations , January 2018 in “International Journal of Trichology”

In this study, minoxidil significantly downregulated interleukin-1 alpha expression in human keratinocyte cells, suggesting an anti-inflammatory effect that may be a mechanism of action in treating alopecia.

research Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata

1 citations , July 2012 in “Nasza Dermatologia Online”

This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.

research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.

53 citations , June 1993 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Day 1 vs Day 168 (today) of defeating the norwood reaper

1528 upvotes 2 years ago

The user achieved significant hair regrowth using topical 5% minoxidil and oral 1mg finasteride daily, especially around the temples. They experienced minimal side effects, with initial difficulty maintaining erections that resolved after a few weeks.

community 1 year of finasteride, minoxidil and dutasteride

902 upvotes 1 month ago

A 26-year-old shared their successful hair regrowth journey using finasteride, minoxidil, and dutasteride, along with a custom minoxidil solution containing progesterone, cortisone, alpha 5 estradiol, menthol, caffeine, and melatonin. They experienced no side effects but noted that stopping the medications would reverse the progress.

community Microneedling only with rosemary

in Microneedling 2 years ago

A user asked if microneedling, massages, and essential oils can prevent further hair loss in the crown area without using drugs. The response indicated that without a 5-alpha-reductase inhibitor, hair loss will likely continue.

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learn tamsulosin

What is tamsulosin and how is it used in treatments related to hair loss? Tamsulosin is a prescription alpha-1 blocker approved for benign prostatic hyperplasia; no human trial has tested it for hair loss, and there are no dosing protocols or safety data for that use. Its connection to hair is a receptor-biology hypothesis, not a treatment.