Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients With or Without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1

January 2023 in “ Annals of Dermatology ”

Satoshi Koyama, Nagisa Yoshihara, Atsushi Takagi, Etsuko Komiyama, A. Oka, Shigaku Ikeda

alopecia areata CCHCR1 steroid treatment hair morphological abnormalities

TLDR Patients with a specific genetic variant have more severe alopecia areata and higher recurrence rates.

The study investigated the clinical characteristics of alopecia areata (AA) patients with a nonsynonymous variant of the Coiled-Coil Alpha-Helical Rod Protein 1 (<i>CCHCR1</i>). It was found that patients with this variant exhibited a high recurrence rate of AA and hair morphological abnormalities. These findings suggested that the presence of the <i>CCHCR1</i> variant could be associated with more severe manifestations of AA, potentially influencing treatment outcomes and recurrence rates.

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