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Did you mean Aldo-Keto Reductase Family 1 Member C3?

Glossary Aldo-Keto Reductase Family 1 Member C3

enzyme involved in hormone metabolism affecting hair growth and alopecia

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) is an enzyme that plays a crucial role in the metabolism of steroids, prostaglandins, and other compounds. It is involved in the conversion of hormones like testosterone and estrogen, which can influence various physiological processes, including hair growth and the development of conditions like alopecia.

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research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Inflammation and Regeneration”

This study found that androgen inactivation pathways in scalp sebaceous glands change with age, specifically noting that AKR1C expression, including AKR1C4 previously thought liver-specific, declines with age and is sex dependent, which could impact hair follicle health during aging.

research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Figshare”

This research reported that AKR1C enzyme expression, particularly AKR1C4, in scalp sebaceous glands decreases with age, suggesting potential age-related changes in androgen metabolism affecting hair follicle health. Additionally, sulforaphane treatment increased AKR1C expression in related cell types.

research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Figshare”

In this study, researchers found that androgen receptor expression and AKR1C-mediated androgen inactivation, including AKR1C4, are prominent in scalp sebaceous glands, with AKR1C expression decreasing with age and differing by sex, suggesting these changes may impact hair follicle health as people age.

Unraveling the Link Between Insulin Resistance and Androgen Excess

research Unravelling the link between insulin resistance and androgen excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.

research The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease

31 citations , March 2016 in “Journal of Investigative Dermatology”

AKR1B10 enzyme may cause keloid scars and could be a treatment target.

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community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

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