learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
Search
forLearn
3 / 3 resultslearn Overview
learn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
Research
5 / 1000+ resultsresearch Understanding Human Aging and the Fundamental Cell Signaling Link in Age-Related Diseases: The Middle-Aging Hypovascularity Hypoxia Hypothesis
The document explores the "middle-aging hypovascularity hypoxia hypothesis," which links age-related diseases to decreased vascularity and oxygenation during middle age. It emphasizes the role of hormonal signaling, particularly testosterone and estrogen, in reversing hypovascularity, and the impact of nitric oxide (NO) signaling on endothelial dysfunction. The hypothesis suggests that maintaining NO bioavailability through pathways like NO-cGMP could improve vasodilation and tissue oxygenation, potentially mitigating diseases such as type 2 diabetes, heart failure, and dementia. The review also discusses the testosterone–vascular–inflamm-aging triad, noting that declining testosterone levels can lead to vascular aging. It highlights the potential of PDE5 inhibitors and supplements like L-arginine and curcumin to improve vascular function. The document underscores the importance of understanding oxygen homeostasis and the role of hypoxia-inducible factor (HIF) in protecting against neurodegeneration, while also exploring translational imaging technologies to assess microcirculation changes related to aging.
research Nitroxide Pharmaceutical Development for Age-Related Degeneration and Disease
Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.
research The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-Communicable Chronic Disease
Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.
research Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders
Human umbilical cord stem cell vesicles may help treat aging and related diseases.
research From causes of aging to death from COVID-19
Older age and related diseases increase COVID-19 risk, but anti-aging treatments might help.
Community Join
5 / 1000+ resultscommunity How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.
community Countering oral minoxidil side effects by taking collagen supplements?
Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.
community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment
The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?
After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.
community Why do we get bald from evolutionary perspective
Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.