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Extemporaneous Topical Minoxidil Solutions for the Treatment of Androgenetic Alopecia: Stability Studies and Incorporation Tests of Active Pharmaceutical Ingredients in Aloplus Total Base

research Extemporaneous Topical Minoxidil Solutions for the Treatment of Androgenetic Alopecia- Stability Studies and Incorporation Tests of Active Pharmaceutical Ingredients in Aloplus Total Base.

February 2024 in “PubMed”

This study reported that minoxidil lotions produced using a propylene glycol-free base, Aloplus Total, demonstrated high minoxidil solubility and maintained chemical and physical stability for over 180 days, suggesting suitability for enhanced topical treatments of androgenetic alopecia.

research Povidone-iodine nail solution is active in treating chemotherapy-associated paronychia

May 2015 in “Journal of The American Academy of Dermatology”

Povidone-iodine nail solution effectively treats nail infections caused by chemotherapy.

A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical Solution (0.01%, 0.02%, and 0.05% w/v) in Male Subjects With Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical Solution (0.01%, 0.02%, and 0.05% w/v) in Male Subjects With Androgenetic Alopecia

August 2025 in “Cureus”

This phase II study found that a 0.05% topical dutasteride solution was more effective than oral finasteride (1 mg/day) in increasing hair count and width in males with androgenetic alopecia over 24 weeks, without causing irritation.

research 284 Backhousia citriodora leaf extract: A new active solution to control hyper-seborrhea for multi-ethnic skins

1 citations , September 2017 in “Journal of Investigative Dermatology”

This research observed that Backhousia citriodora leaf extract effectively reduced sebum production and improved sebum composition across different ethnicities, significantly decreasing skin oiliness and the likelihood of shiny skin when used in a cream applied twice daily for 28 days.

Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

research Positive lymphocyte transformation test in a patient with allergic contact dermatitis of the scalp after short-term use of topical minoxidil solution

38 citations , June 2005 in “Contact Dermatitis”

This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.

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Community Join

5 / 957 results

community Musely advertising a 3 month supply in one bottle when active ingredients degrade in 6 weeks.

4 upvotes 1 year ago

Musely sells a hair topical solution containing latanoprost, which degrades in 6 weeks, yet they market it as a 3-month supply. Concerns are raised about the product's effectiveness and the company's sales strategy.

community Has anyone had success with lipodermal solution?

1 upvotes 1 year ago

The conversation discusses using a lipodermal solution for hair loss, with concerns about side effects from multiple active ingredients. Users mention experiences with minoxidil, finasteride, and dutasteride, noting side effects like brain fog and sexual issues.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community PP405 Never Worked: the follicles were already activated at baseline

17 upvotes 2 months ago

PP405 was ineffective for hair growth as some follicles were already active before treatment, raising doubts about its efficacy. Users discussed other hair loss treatments like Minoxidil, finasteride, and RU58841, expressing skepticism and hope for future solutions.

community Do botanical oils actually improve absorption in a minoxidil and finasteride topical?

2 upvotes 1 month ago

A user is using a pharmacy-compounded topical treatment for hair loss containing minoxidil, finasteride, azelaic acid, caffeine, and an oil blend including argan, jojoba, castor, rosemary, tea tree, and nettle oils. They are questioning if the oil blend improves absorption of the active ingredients compared to a simple alcohol/propylene glycol solution.

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Learn

8 / 801 results

learn Scalp Micropigmentation

What is Scalp Micropigmentation and how does it help people with visible hair loss? Scalp Micropigmentation creates the illusion of hair follicles on the scalp for visible hair loss.

learn Beta Polypeptide

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Thymosin Beta 4

learn Mesotherapy

technique to inject very small amounts of beneficial chemicals into the scalp

learn sh-Polypeptide-7

learn Glycerin

Can glycerin be used in combination with active ingredients like minoxidil or tretinoin? Glycerin is a common humectant that formulators treat as compatible with topical actives, but no published trial has tested it alongside minoxidil or tretinoin, so any benefit is comfort rather than a proven effect. Tretinoin is prescription-only and carries pregnancy warnings.

learn Pyrithione Zinc

Can pyrithione zinc be combined with other active ingredients like ketoconazole or minoxidil? Pyrithione zinc can be safely combined with ketoconazole and minoxidil.

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