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Glossary Dihydrotestosterone

potent androgen hormone derived from testosterone

Dihydrotestosterone (DHT) is a potent androgen hormone derived from testosterone through the action of the enzyme 5-alpha-reductase. It plays a crucial role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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Research

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Preponderance of Serum and Intra-Hepatic 5α-Dihydrotestosterone in Males with Hepatocellular Carcinoma Despite Low Circulating Androgen Levels

research Preponderance of serum and intra-hepatic 5α-dihydrotestosterone in males with hepatocellular carcinoma despite low circulating androgen levels

8 citations , January 1986 in “Journal of hepatology”

This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.

An Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry-Based Candidate Reference Measurement Procedure for the Quantification of 5-Alpha-Dihydrotestosterone in Human Serum and Plasma

research An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasma

January 2026 in “Clinical Chemistry and Laboratory Medicine (CCLM)”

This study reported high analytical performance of an RMP for DHT quantification, with the ability to differentiate between 5α-DHT and 5β-DHT isomers, making it suitable for routine assay standardization and clinical sample evaluation.

research 5 Dihydrotestosterone metabolism

22 citations , May 1986 in “Clinics in endocrinology and metabolism”

This study found that women with lower 2D:4D ratios and fewer middle-phalangeal hairs reported more adverse side effects from oral contraceptives, suggesting these features may predict hormonal contraceptive side effects.

research DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

235 citations , September 2004 in “The Journal of urology/The journal of urology”

This review discusses the role of dihydrotestosterone in benign prostatic hyperplasia and reports no new results; the authors highlight 5alpha-reductase inhibitors as a well-established treatment option.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

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Community Join

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community Does caffeine inhibit 5-α-reductase?

4 upvotes 6 years ago

Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.

community 5 years post hair transplant, 3 months on minoxidil only

326 upvotes 8 months ago

The user had a hair transplant five years ago and started using minoxidil three months ago. Commenters recommend adding finasteride or other DHT blockers to prevent further hair loss and maintain results.

community Finasteride - 5 years and my expierience

128 upvotes 1 week ago

A 26-year-old shared their 5-year experience using finasteride and minoxidil for hair loss, noting initial improvements but later experiencing reduced libido and erection quality, leading them to switch from oral to topical finasteride. They advise starting with a low-dose topical solution and emphasize making informed decisions, acknowledging that while finasteride is effective, it can have side effects.

community 6 Months topical 5% minoxidil twice a day.

in Progress Pictures 147 upvotes 10 months ago

The user has been using topical 5% minoxidil for six months with minimal results and is worried about greasy hair and potential side effects of adding finasteride. Others suggest combining minoxidil with finasteride for better results, while discussing potential side effects like erectile dysfunction.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

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Learn

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learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

learn Overview

learn Minoxidil

Minoxidil 2%, 5% and 10% which is better to use? In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%. There is no approved 10% product and no head-to-head trial showing it beats 5%; higher strengths mainly add irritation and systemic absorption. Approved strengths differ by sex, so check the label for your product.

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