Search

for
Search:

Research

5 / 1000+ results

Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

This study found that GI198745 acts as a time-dependent inhibitor of rat 5α-reductase type 2 but a rapid-equilibrium inhibitor of type 1, potentially making it more effective than finasteride in preventing rat prostate growth.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

research Analysis of genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia

15 citations , April 2003 in “Journal of Dermatological Science”

This study found no significant associations between the polymorphisms of SRD5A1 and SRD5A2 genes and androgenetic alopecia, clinical types of baldness, or response to finasteride in Koreans.

research Comparison of Microneedling with Platelet Rich Plasma vs Minoxidil (5%)+Finasteride (0.1%) Topical Therapy in Androgenetic Alopecia: A Randomised Clinical Study

January 2023 in “Journal of Clinical and Diagnostic Research”

This study compared the effectiveness and safety of microneedling with PRP versus minoxidil and finasteride topical therapy in adult males with androgenetic alopecia, finding similar hair density improvements in both groups, though microneedling with PRP had a quicker onset of action.

research Comprehensive Evaluation of Tectona grandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties

November 2025 in “ACS Omega”

This study found that compounds from *Tectona grandis* leaves showed moderate inhibition of steroid 5α-reductase, a factor in androgenetic alopecia, and exhibited anti-inflammatory properties by inhibiting nitric oxide and pro-inflammatory cytokines IL-1β and IL-6 in vitro, suggesting potential dual-action benefits for AGA management.

View more "1 5mm" in research →

Community Join

5 / 1000+ results

community 1 year and 5 months progress oral fin + topical min

331 upvotes 2 years ago

User shared progress on hair regrowth using 1.25 mg finasteride daily, 5% minoxidil, and a 1.5 mm dermaroller twice a week, with no side effects. Users discussed shedding phases, application methods, and the necessity of continuous treatment to maintain results.

community Dutasteride 1.5 years and Oral Minoxidil 1 year progress!

in Is this regrowth? 42 upvotes 1 year ago

A user switched from finasteride to dutasteride and added oral minoxidil for hair loss but saw limited improvement. They are considering increasing doses, trying RU58841, and possibly a hair transplant, while others suggest checking for vitamin deficiencies.

community Update 1.5 years on finasteride. My experience so far.

in Progress Pictures 265 upvotes 1 year ago

The user experienced initial hair regrowth using finasteride, minoxidil, and a dermaroller but faced setbacks after a treatment break and dry scalp issues. They are considering switching treatments and have added ketoconazole shampoo and reservatol plus to their regimen.

community 5mg Min + DermaRoll 1.5mm Weekly + Keto/Salicyclic alternative day + 0.5 mg Dut. Norwood 6, should I go to 2.5 mg Dut? 33 Year old

84 upvotes 1 month ago

The user is considering increasing their dose of Dutasteride from 0.5 mg to 2.5 mg while using Minoxidil, DermaRoll, and other treatments for hair regrowth after multiple hair transplants. Many responses suggest accepting baldness or using a hair system instead of continuing with medications.

community Why are we using 1.5mm for microneedling? Evidence says we don't need to.

39 upvotes 4 months ago

Shorter microneedle lengths, like 0.5mm, may be more effective and safer for hair regrowth than longer ones, such as 1.5mm, which can cause more pain and risk. Users report success with various regimens, including minoxidil, finasteride, and other topicals, alongside microneedling.

View more "1 5mm" in community →

Experts

6 / 20 results

All 20 expert results →

Clinics

6 / 12 results

All 12 clinic results →

Learn

7 / 801 results

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Overview

learn 1,2-Hexanediol

learn Tripeptide-1

learn Biotinoyl tripeptide 1

learn Ketoconazole

Is there a difference between 1% and 2% ketoconazole? The documented differences are strength and supply: 1% ketoconazole shampoo is sold over the counter while 2% is usually prescription-only, and almost all of the trial evidence — including a 2015 Cochrane review — was gathered on the 2% shampoo rather than in a head-to-head comparison of the two strengths.

learn Biotin

Biotin, Biotinyl-GHK, biotinoyl-tripeptide-1… are they not the same? Biotin, Biotinyl-GHK, and Biotinoyl-Tripeptide-1 are different compounds with distinct functions.

View more "1 5mm" in learn →