A Case of Lean Idiopathic Hirsutism Not Having Insulin Resistance Unresponsive to Conventional Treatment for Hirsutism: A Case Report
June 2018
in “
Global Journal of Reproductive Medicine
”
Studysummary This case report describes a 28-year-old woman with facial, abdominal, and thigh hirsutism who showed little improvement after 5 months of Metformin and spironolactone treatment.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report focused on a 28-year-old woman with idiopathic hirsutism (IH) who did not exhibit insulin resistance and was unresponsive to conventional treatments such as Metformin and spironolactone. Despite having normal serum testosterone levels and regular menstrual cycles, she experienced significant terminal hair growth. The report emphasized that IH might be linked to increased skin 5 alpha-reductase activity, influencing dihydrotestosterone production and hair follicle response. Treatment involved oral contraceptives with drosperinone and low-dose flutamide to lower free testosterone levels and control hair growth. It was suggested that IH diagnosis should be limited to hirsute patients with normal ovulatory function and androgen levels, and highlighted the potential of new therapies like laser epilation and eflornithine cream.
