Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

March 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Amanda Kowalczyk, Maria Chikina, Nathan L Clark

hair shaft structure hair growth hair cycling KRT2 KRT35 PKP1 PTPRM noncoding regions regulatory genes microRNAs mir205 ELF3 FOXC1

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary In this study, researchers used an evolutionary-rate-based method to identify genetic elements associated with reduced hair in mammals, finding a dichotomy between accelerated coding sequences and noncoding regulatory elements influencing hair growth.

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