Surface-Induced Mechano-Regulation of Macrophages: Emerging Strategies for Immunotherapy

    May 2026 in “ Med-X ”
    Jing Yang, Rui Liu, Xiaoheng Liu, Yang Song
    Studysummary This review highlights that surface mechanical regulation can program macrophage behavior through specific mechanical cues on material surfaces, potentially advancing immunotherapies and regenerative medicine by enabling precise control over macrophage functions.
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    Research cited in this study 3

    1. Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages Advanced science · 2024
    2. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    3. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019