Cutaneous Transcriptome Analysis in NIH Hairless Mice

August 2017 in “ PloS one ”

Zhong-Hao Ji, Jian Chen, Wei Gao, Jinyu Zhang, Fu‐Shi Quan, Jian Hu, Bao Yuan, Wenzhi Ren

hair growth cycle H&E staining RNA-Seq differentially expressed genes basal cell carcinoma cell cycle Hippo signaling pathway Hedgehog signaling pathway Wnt signaling pathway cell proliferation hair follicle development q-PCR Pik3r1 Pik3r3 hematoxylin and eosin staining RNA sequencing quantitative PCR

Studysummary This study found that NIH hairless mice exhibit abnormalities in hair growth and immune-related pathways, with Pik3r1 and Pik3r3 identified as key genes for further investigation.

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