P63 in Skin Homeostasis and Disease: Molecular Mechanisms and Therapeutic Potentials

    March 2026 in “ Cell Death Discovery ”
    Yujia Cong, Zhenglin He, Haiping Hao … Xianling Cong
    Studysummary In this comprehensive review, researchers examine the p63 gene's crucial role in skin development and pathology, highlighting its regulation of cell processes and its potential therapeutic implications for disorders like ectodermal dysplasia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 9

    1. Genome-Wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses Cancer Research Communications · 2024
    2. Photobiomodulation Facilitates Rat Cutaneous Wound Healing by Promoting Epidermal Stem Cells and Hair Follicle Stem Cells Proliferation Tissue Engineering and Regenerative Medicine · 2023
    3. P63: A Crucial Player In Epithelial Stemness Regulation Oncogene · 2023
    4. A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2020
    5. Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling PLOS genetics · 2019
    6. Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization Cell death and differentiation · 2016
    7. Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes Wound repair and regeneration · 2015
    8. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    9. P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis The Journal of Cell Biology · 2011