The Effect of Vitamin D on the Hormonal Profile of Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

August 2024 in “ Middle East Fertility Society Journal ”

Mohsen Kazeminia, Fatemeh Rajati, Roumina Rasulehvandi, Mojgan Rajati

vitamin D polycystic ovarian syndrome PCOS DHEAS SHBG testosterone LH FAI FSH AMH

TLDR Vitamin D may help improve hormone levels in women with PCOS.

The systematic review and meta-analysis investigated the effect of vitamin D on the hormonal profile of women with polycystic ovarian syndrome (PCOS) by analyzing 19 studies with 900 participants. The study found that vitamin D supplementation significantly improved levels of several hormones, including DHEAS, SHBG, testosterone, LH, and FAI, but not FSH and AMH. It concluded that 8-week interventions were more effective than 12-week ones, although results varied based on factors like dose and baseline vitamin D levels. Despite some inconsistencies and limitations, the findings suggest vitamin D could help manage hormonal imbalances in women with PCOS, warranting further research.

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