Inverse Correlation Between Vitamin D and CRP Levels in Alopecia Areata: A Pilot Study

September 2023 in “ Journal of Cosmetic Dermatology ”

Fatemeh Mokhtari, Zakiye Ganjei, Maral Yazdanpanah, Mohsen Hosseini

vitamin D C-reactive protein CRP alopecia areata AA alopecia universalis non-scarring hair loss immunomodulatory effects

From the encyclopedia

Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study found that patients with alopecia areata who have low vitamin D levels and high CRP levels are more likely to develop the universalis form of the condition, indicating a need for more aggressive treatment in these cases.

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This pilot study involving 40 patients found a significant inverse correlation between vitamin D and C-reactive protein (CRP) levels in individuals with alopecia areata (AA), a type of non-scarring hair loss. Lower vitamin D levels were associated with higher CRP levels, possibly due to vitamin D's immunomodulatory effects. Patients with vitamin D levels under 15 and CRP levels over 16.5 were more likely to develop alopecia universalis, a severe form of AA. However, due to the small sample size, further studies are needed to confirm these findings.

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Research cited in this study

14 / 14 results

research Evaluation of Several Immune and Inflammatory Indicators and Their Association with Alopecia Areata

5 citations , September 2021 in “Journal of cosmetic dermatology”

This study found that alopecia areata patients had significantly abnormal T3, T4, TPOAbs, ANA, and lower vitamin D levels compared to healthy controls.

research Study of Vitamin D Deficiency in Patients With Alopecia Areata Attending a Dermatology Center in Iran

1 citations , June 2021 in “International Journal of Dermatology”

This study found that patients with alopecia areata had significantly lower serum vitamin D levels compared to controls, but these levels did not impact disease severity or pattern.

research Serum Vitamin D Levels and Alopecia Areata: A Hospital-Based Case-Control Study from North India

20 citations , January 2019 in “International journal of trichology”

This study found that patients with alopecia areata had significantly lower Vitamin D levels compared to controls, with a negative correlation between Vitamin D levels and disease severity.

research An Investigation of Vitamin D Status in Alopecia Areata

37 citations , June 2018 in “Clinical and Experimental Medicine”

This study found that patients with alopecia areata had significant systemic inflammation and vitamin D deficiency, with both conditions more pronounced as disease severity increased.

research Increased Prevalence of Vitamin D Deficiency in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis

48 citations , April 2018 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study found that individuals with alopecia areata had significantly lower serum vitamin D levels and a higher prevalence of vitamin D deficiency compared to people without the condition.

research Alopecia Areata Is Associated With Increased Expression of Heart Disease Biomarker Cardiac Troponin I

19 citations , January 2018 in “Acta dermato-venereologica”

In this study, the researchers observed that subjects with alopecia areata had the highest plasma level of cardiac troponin I, followed by those with androgenetic alopecia, and the lowest levels in individuals without hair loss.

research Vitamin D Deficiency in Patients With Alopecia Areata: A Systematic Review and Meta-Analysis

32 citations , December 2017 in “Journal of the American Academy of Dermatology”

Alopecia areata patients often have low vitamin D levels.

research Factors Associated With Severity Of Alopecia Areata

63 citations , January 2017 in “Annals of Dermatology”

More research is needed to understand alopecia areata severity.

research Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata

18 citations , October 2014 in “Indian Journal of Dermatology”

This study found that patients with alopecia areata have lower levels of RBC folate, correlating negatively with the disease's severity and extent.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

275 citations , November 2002 in “International Journal of Dermatology”

This study found that among an Asian population with alopecia areata, commonly first episodes occurred before age 40, with severe cases linked to psychological effects and treatments showing significant regrowth.

research Alopecia Areata in Korea (1982–1994)

46 citations , November 1995 in “The Journal of Dermatology”

This study found that immunotherapy with DNCB or DPCP showed better therapeutic effects than intralesional triamcinolone acetonide for patients with bald areas greater than 50 cm², including alopecia totalis and universalis.

research Alkaline Phosphatase in Alopecia Areata

23 citations , September 1957 in “Archives of Dermatology”

This study investigated alkaline phosphatase activity in scalp biopsies from patients with alopecia areata and totalis, but provides no new conclusive clinical results.